Lipid Metabolism and Cardiac Test Markers: Importance of ...

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Standardization and Traceability 28
Reasons for testing • To identify individuals at increased risk of disease and/or monitor disease management • To develop epidemiologic data from which to establish public health strategies for disease management G. Myers, CDC, with permission
Page 1 and 2: Lipid Metabolism and Cardiac Test M
Page 3 and 4: Our Common Goal: Quality Healthcare
Page 5 and 6: CLSI Name Name change in 2005 to re
Page 7 and 8: CLSI’s Mission To develop best pr
Page 9 and 10: CLSI Consensus Process Government B
Page 11 and 12: CLSI products • Standards • Gui
Page 13 and 14: Use of CLSI Documents • Regulator
Page 15 and 16: CLSI Members & Volunteers Diverse r
Page 17 and 18: Global Health Partnerships • Gran
Page 19 and 20: Global Health Partnerships Current
Page 21 and 22: CLSI’s Key Global Activities Inte
Page 23 and 24: Standards and Guidelines 23
Page 25 and 26: Why do Standards Matter? • Raise
Page 27: Standard or Guideline? • A standa
Page 31 and 32: Standardization of Laboratory Resul
Page 33 and 34: Traceability in Laboratory Medicine
Page 35 and 36: Standardization vs. Proficiency Tes
Page 37 and 38: When and Why Is Traceability Most I
Page 39 and 40: Calibration Traceability Scheme Pri
Page 41 and 42: Reference Measurement Procedure, HD
Page 43 and 44: Beta-quantification limitations •
Page 45 and 46: Routine Method SIGNAL Trueness (acc
Page 47 and 48: Lipids: method evaluation • Inter
Page 49 and 50: Homogeneous HDL-C: approach 1 Step
Page 51 and 52: Homogeneous LDL-C: analogous to HDL
Page 53 and 54: Why is standardization important cl
Page 55 and 56: Comparison of HDL and LDL Cholester
Page 57 and 58: Comparison of HDL and LDL Cholester
Page 59 and 60: National Academy of Clinical Bioche
Page 61 and 62: NACB LMPG: Biomarkers of Acute Coro
Page 63 and 64: Risk Stratification of Acute Corona
Page 65 and 66: NACB Recommendations (Con’t) •
Page 67 and 68: Death or MI Troponin as a Marker of
Page 69 and 70: Limitations of Troponin • Not an
Page 71 and 72: FDA Approved Cardiac Troponin Assay
Page 73 and 74: Limitations of Myoglobin • Can be
Page 75 and 76: NACB Recommendations-BNP • Plasma
Page 77 and 78: BNP and NT-proBNP - NACB Recommenda
Page 79 and 80:
Emerging Risk Factors for Cardiovas
Page 81 and 82:
Inflammation Biomarkers and Cardiov
Page 83 and 84:
Apolipoproteins A-I and B and Cardi
Page 85 and 86:
Homocysteine (Hcy) and Cardiovascul
Page 87 and 88:
NACB LMPG Point of Care Testing (Pu
Page 89 and 90:
NACB Guideline Recommendations-”E
Page 91 and 92:
Summary • CLSI is an internationa
Page 93:
THANK YOU FOR YOUR ATTENTION 93
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