Analgesic and anti-inflammatory studies of the methanol

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Res. J. Medicine & Med. Sci., 5(1): 106-110, 2010 Table 3: Percentage inhibition expressed by methanol extract and ketoprofen on carrageenan induced oedema in rats. Treatment Dose % INHIBITION AT VARIOUS TIME Mean % inhibition ------------------------------------------------------------------------------------------- 1h 2h 3h 4h 5h Normal Saline 10ml/Kg - - - - - - ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Extract 50mg/Kg 63.6 52.2 69 61.4 80.7 64.4 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Extract 100mg/Kg 51.7 59.7 72.2 56.6 72 62.4 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Extract 200mg/Kg 70.3 72.6 68 70 78.6 71.9 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ketoprofen 10mg/Kg 46.6 51.2 66.2 44.1 41.8 50 Table 4: Effect of the methanol extract of I. pulchra on carrageenan- induced paw oedema in rats. Treatment Dose Mean Paw Oedema Diametre± SEM (cm) ---------------------------------------------------------------------------------------------------------------------------- 1h 2 h 3 h 4h 5h Normal saline 10ml/Kg 0.236±0.146 0.402±0.001 0.438±0.188 0.290±0.290 0.364±0.037 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Extract 50mg/Kg 0.086±0.021 b 0.192±0.022 b 0.136±0.018 b 0.112±0.011 b 0.07±0.020 b ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Extract 100mg/Kg 0.114±0.017 b 0.162±0.036 b 0.122±0.023 b 0.126±0.035 b 0.102±0.017 b ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Extract 200mg/Kg 0.07±0.014 b 0.11±0.038 b 0.14±0.035 b 0.086±0.019 b 0.078±0.026 b ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Ketoprofen 10mg/Kg 0.126±0.010 b 0.196±0.007 b 0.148±0.021 b 0.162±0.021 b 0.212±0.020 b a P
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