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1.<br />
N<br />
O<br />
1. LDA, TMSCl, THF<br />
TBDMSOTf,<br />
CH 2 Cl 2 ,-78°C<br />
1. NaH, CS 2 then MeI<br />
O<br />
O<br />
2. Pd(OAc) 2 ,CH 3 CN<br />
O 2 atmosphere<br />
2.<br />
THF, -78 °C<br />
MgBr<br />
2. nBu 4 NF<br />
NH 2<br />
N<br />
Ph<br />
MeOH<br />
Ph<br />
1. nBu 3 SnH, AIBN,<br />
syringe pump, 20h<br />
2. TsOH, MeOH<br />
1. MeLi<br />
2. SOCl 2 ,py<br />
3. TsOH, CH 2 Cl 2<br />
H