GIST Pathology PowerPoint by Dr. Rosenberg - The Life Raft Group
GIST Pathology PowerPoint by Dr. Rosenberg - The Life Raft Group
GIST Pathology PowerPoint by Dr. Rosenberg - The Life Raft Group
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Treatment<br />
GI Stromal Tumors<br />
Complete resection; Conventional chemotherapy fails<br />
Imatinib - inhibitor of c-Kit<br />
most effective<br />
Mechanism of Action of Gleevec<br />
ATP<br />
PO 4<br />
Gleevec<br />
ATP<br />
TK<br />
TK<br />
Substrate<br />
Substrate<br />
p210<br />
Bcr-Abl<br />
p210<br />
Bcr-Abl<br />
Gleevec is not entirely selective for Bcr-Abl; it also inhibits c-Kit and PDGF-R.
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