Pittcon Today - Chemical & Engineering News

16 PITTCON TODAY :: TUESDAY :: March 13 2012 :: Orlando Orlando :: March 13 2012 :: TUESDAY :: PITTCON TODAY 17PartnersTeam toProvide Rangeof Products,ServicesHanna Instruments has partneredwith Brechbühler as its exclusivedistributor in Switzerland for scientificanalytical instrumentation.Hanna, a manufacturer of electroanalytical instrumentation, andBrechbühler AG, an independent distributorof scientific equipment, haveteamed to provide users of analyticaldevices with an exceptional combinationof products and service.The partnership combines Hanna’shigh quality devices for lab, environmental,food, and industry applicationswith Brechbühler’s excellentservice and support. It provides Hannawith a strong presence in Switzerland,and Brechbühler AG with highquality, cost effective devices.“Hanna’s products fit perfectlyin our product portfolio,” said PeterPichler, president/CEO of Brechbühler.“Additionally, the companiesshare a common goal of providinghigh quality products and excellentcustomer support.”Brechbühler AG will representHanna’s entire product catalog, spanningover 3000 products, includinghandheld pH checkers, portablemultiparameter units, and laboratorygrade titrators. In addition, BrechbühlerAG provides comprehensiveservice including user training; seminarsand workshops; application,maintenance and support.The two companies combined havemore than 70 years of experience; Hannawith three decades of technologicalknow-how, international experienceand industry knowledge, and Brechbühlewith 40 years of experience supplyingand supporting the local Swissanalytical community.The partnership continues Hanna’sphilosophy of working closelywith regional companies in order toprovide exceptional sales and supportat the local level.Visit Hanna Instruments at Booth2959.Quality by Design in HPLC Method DevelopmentThe common practice in developingan HPLC method, for many years,has been a trial and error approach.Often after the validation process wasstarted, one found several surprisingobservations, such as new peaks, orthe disappearance of other peaks, orchanges in critical peak pairs.The typical reaction was then togo back to the development processand to try to improve the separationby carrying out several teststeps: trying to test quality intothe method. This time-consumingprocess can be avoided by applyingQuality by Design (QbD) principles,which plan or design quality intoa method from the outset. A wellestablishedmeans of implementingQbD principles into HPLC methoddevelopment is the use of modelingsoftware, such as DryLab.To apply QbD principles to thedevelopment of HPLC methodsmeans to focus on method understandingand good science. ThroughDryLab, scientifically sound retentionmodeling combined with deepchromatographic understandingprovide the necessary QbD frameworkfor HPLC, achieving optimalrobust methods in a transparentand demonstrable way.Retention behavior is modeled insuch a way that the influence of allsignificant parameters alone and incombination is known, quantified,and visualized. In the HPLC methoddevelopment process, relationshipsbetween parameters and their effecton the result are well understood.This translates into a richer chromatographicunderstanding and facilitatesa better scientific work.Rather than running randomtest arrangements—necessarywhen applying statistical analysis—tofulfill QbD conditions, HPLCmethod development with the newestthree dimensional DryLab (Fig.1) is achieved by running a smallnumber of meaningful experiments.From these a large number (morethan a million) of virtual experimentscan be derived and the bestone found with one mouse click.Visit Molnar at Booth 2085.Figure 1: 3-D retention models for gradient time, temperature and ternary eluent composition vs. critical resolution in color(warm colors represent high values of critical resolution and cold colors represent low values)