Tumor-infiltrating lymphocyte (TIL) - Winship Cancer Institute of ...

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Chimeric TcR transduced T cells for CLLPorter, DL et al N Engl J Med. 2011 August 25; 365(8): 725–733.
PD effect <strong>of</strong> adoptively transferred TcRtransduced cells: cytokine levelsPorter, DL et al N Engl J Med. 2011 August 25; 365(8): 725–733.
Page 1 and 2: Winship Regional Melanoma Conferenc
Page 3 and 4: What Is Adoptive‐Cell Therapy?•
Page 5 and 6: TIL cultures set-up n = 568Immediat
Page 7 and 8: ResultsImpact of Prior Therapy with
Page 9 and 10: APre-REPPerforin38.7CD8Perforin Per
Page 11 and 12: Lympho‐depletion: important role
Page 13 and 14: Efficacy of TIL with lymphodepletio
Page 15 and 16: Survival by Prior Therapy In NCI‐
Page 17 and 18: Adoptive cell therapy after lymphod
Page 19 and 20: Waterfall plot of percentage change
Page 21 and 22: Comparison of PD-1, BTLA, and TIM-3
Page 23 and 24: Outcome is associated with number o
Page 25: TcR transduced T cells for adoptive
Page 29 and 30: Conclusions• TIL are a promising

Tumor-infiltrating lymphocyte (TIL) - Winship Cancer Institute of ...

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