<strong>The</strong> <strong>Pathophysiology</strong> <strong>of</strong> <strong>Irritable</strong> <strong>Bowel</strong> Syndrome CMEFaculty and DisclosuresAs an organization accredited by the ACCME, <strong>Medscape</strong>, LLC, requires everyone who is in a position to control the content <strong>of</strong> aneducation activity to disclose all relevant financial relationships with any commercial interest. <strong>The</strong> ACCME defines “relevantfinancial relationships” as financial relationships in any amount, occurring within the past 12 months, including financialrelationships <strong>of</strong> a spouse or life partner, that could create a conflict <strong>of</strong> interest.<strong>Medscape</strong>, LLC, encourages Authors to identify investigational products or <strong>of</strong>f-label uses <strong>of</strong> products regulated by the US Foodand Drug Administration, at first mention and where appropriate in the content.AuthorMichael Camilleri, MDPr<strong>of</strong>essor <strong>of</strong> Medicine, Pharmacology, and Physiology, Mayo Clinic, Rochester, MinnesotaDisclosure: Michael Camilleri, MD, has disclosed the following relevant financial relationships:Served as a speaker or a member <strong>of</strong> a speakers bureau for: ShireReceived grants for clinical research from: Salix Pharmaceuticals, Sk Life Science, and Tsumura & Co.Dr Camilleri does not intend to discuss <strong>of</strong>f-label uses <strong>of</strong> drugs, mechanical devices, biologics, or diagnostics approved by the FDAfor use in the United States.Dr Camilleri does not intend to discuss investigational drugs, mechanical devices, biologics, or diagnostics not approved by theFDA for use in the United States.EditorsJulia MuinoScientific Director, <strong>Medscape</strong>, LLCDisclosure: Julia Muino has disclosed no relevant financial relationships.Kristen L. DascoliClinical Editor, <strong>Medscape</strong>, LLCDisclosure: Kristen L. Dascoli has disclosed no relevant financial relationships.CME ReviewerNafeez Zawahir, MDCME Clinical Director, <strong>Medscape</strong>, LLCDisclosure: Nafeez Zawahir, MD, has disclosed no relevant financial relationships.Pg.4
www.medscape.org/lecture/ibs/pathophysiologySlide 1.Dr Michael Camilleri: Hello. I am Michael Camilleri, pr<strong>of</strong>essor <strong>of</strong> medicine, pharmacology, and physiology at the Mayo Clinic inRochester, Minnesota. I would like to welcome you to this program titled “<strong>Pathophysiology</strong> <strong>of</strong> <strong>Irritable</strong> <strong>Bowel</strong> Syndrome.”Slide 2.<strong>Irritable</strong> bowel syndrome (IBS) affects 10% to 20% <strong>of</strong> the population in developed countries. [1] <strong>The</strong> diagnosis <strong>of</strong> IBS is traditionallybased on the presence <strong>of</strong> symptoms <strong>of</strong> recurrent abdominal pain or discomfort at least 3 days per month in the previous 3 monthsin association with 2 or more <strong>of</strong> the following: an improvement with defecation, an onset that is associated with a change in thefrequency <strong>of</strong> bowel movements, or an onset associated with a change in the form or appearance <strong>of</strong> stool. [2]Pg.5