Cetyl Myristoleate: Mechanisms of Action - OLEIA

Mata P, Alonso R, Lopez-Miranda 3, et al. Effect of dietary fat saturation on LDL oxidation andmonocyte adhesion to human endothelial cells in vitro. Arterioscler Thromb Vasc Biol 16:1347-1355, 1996.Perez-Jimenez F, Castro P, Lopez-Miranda J, et al. Circulating levels of endothelial functionare modulated by dietary monounsaturated fat. Atherosclerosis 145: 351-358, 1999.Vicennati V, Vottero A, Friedman C, Papanicolaou DA. Hormonal regulation of interleuki-6production in human adipocytes. Int J Obes Relat Metab Disord 26(7): 905-911, 2002.Zaloga GP, Marik P. Lipid modulation and systemic inflammation. Crit Care Clin 17(1): 201-217,2001.Pathway I I IArachidonic acid is one of the primary mediators for inflammation. Fatty acids from fish oil havebeen shown to decrease the amount of arachidonic acid in cell membranes reducingeicosanoid production via cyclooxygenase and lipoxygenase. It is the integration betweenarachidonic acid byproducts and their involvement with leukotriene and proglandins that leadsto inflammation control. It is believed that the fatty acid esters within the cetyl myristoleatecomplex work to limit this eicosanoid production and thereby reduce the inflammatory cascade.Bandeira-Mel C, Bozza PT, Weller PF. The cellular biology of eosinophil eicosanoid formationand function. 3 Allergy Clin Immunol 109(3): 393-400, 2002.Calder PC 1 Grible RF. Polyunsaturated fatty acids, inflammation and immunity. Eur J Clin Nutr56(3): S14-9, 2002.Fabre JE, Goulet JL, Riche E, Nguyen M, Coggins K, Offenbacher S, Koller BH. Transcellularbiosynthesis contributes to the production of leukotrients during inflammatory responses invivo. J Clin Invest 109(10): 1373-80, 2002.Kroetz DL, Zeldin DC. Cytochrome P450 pathways of arachidonic acid metabolism. Curr OpinLipidol 13(3): 273-83, 2002.Pathway IVThere is new, compelling evidence showing that fatty acids have profound impact on cellularregulation and communication (Holthus et al 2001). The primary organs for this process arethe endoplasmic reticulum and Golgi body apparatus. These two cellular structures are themain manufacturers of the cellular signals within the body. While direct evidence for the cetylmyristoleate complex is not available at the present, it is believed that the immediate benefitfound with topical cream containing cetyl myristoleate can only be explained by such rapidcellular communication and regulation.