Gastrointestinal Issues and Study Update--Ranjan Dohil, M.D.

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Outline• <strong>Gastrointestinal</strong> symptoms• Cysteamine absorption study• Enteric-coated cysteamine study
Common GI SymptomsCurrent symptoms• Nausea/ vomiting 83%• Poor appetite 71%• Diarrhea/Constipation 57%• Abdominal Pain 50%• Swallowing difficulties 41%Elenberg E et al. Pediatr Nephrol1998;12:365-70
Page 1: Gastrointestinal Issues in Cystinos
Page 5 and 6: Mechanism of Ulcerogenesis with Cys
Page 7 and 8: Gastric Acid Output Following Cyste
Page 9 and 10: Stomach• Symptom score 9QuickTime
Page 11 and 12: Omeprazole (Prilosec) / Esomeprazol
Page 13 and 14: Does everyone with cystinosis need
Page 15 and 16: Cysteamine Absorption StudyAims•
Page 17: Cysteamine Absorption• Cystinosis
Page 20 and 21: Plasma Cysteamine Concentration in
Page 22 and 23: Mean Change in Leukocyte Cystine Le
Page 25 and 26: Enteric-coated coated Cystagon• T
Page 27 and 28: Enteric-coated coated Cystagon Stud
Page 29 and 30: Mean Gastrin Levels in Cystinosis (
Page 31 and 32: Plasma Cysteamine Profile After Sin
Page 33 and 34: White Cell Cystine Profiles After S
Page 35 and 36: Phase 1White Cell Cystine Levels on
Page 37 and 38: Symptoms on Double Dose EC-Cystagon
Page 39 and 40: Summary• Enteric-release release
Page 41: Acknowledge:• Children and parent
Page 49 and 50: Gastrin Profile in Single Patient w

Gastrointestinal Issues and Study Update--Ranjan Dohil, M.D.

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