CSF/brain smear cytology - Rcpa.tv

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PRACTICAL TIPS:1. Know the cellularity of normal CSF. Any derivation is abnormal. Cells from CSFoften become degenerate (looking atypical) if not processed quickly. Only assesswell-preserved cells.2. Beware starch granules or erythrocytes mimicking cryptococcus. Use polarisedlight.3. Bloody background with entrapped inflammatory cells is unsatisfactory. It shouldnot be assumed to represent true inflammation. Also beware traumatic tapcontaining circulating tumour cells. Need to repeat specimen in these instances.4. Reactive lymphocytosis with activated lymphocytes may mimic lymphoma. Lookfor heterogeneity of the cells. May need flow cytometry in difficult cases. Checkthe serum white cell count.5. Carcinomas often present as single cells, mimicking a melanoma or lymphoma.Need to do immunostains on a cell block to confirm unless there is a known pasthistory.
Fig 1. Normal CSF. Note hypocellularity.Fig 2. Normal chondrocytes.
Page 1 and 2: CSF/brain smear cytologyDr Alpha Ts
Page 3 and 4: -foreign material e.g. shunt-parasi
Page 5: Metastatic melanoma:-cells are larg
Page 9 and 10: Fig 5. Unsatisfactory. Degenerate c
Page 11 and 12: Fig 9. Cryptococcus.Fig 10. Erythro
Page 13 and 14: Fig 13. Metastatic carcinoma with s
Page 15 and 16: Fig 17. Non-Hodgkin lymphoma.Fig 18
Page 17 and 18: Fig 21. Brain fluid cytology: Gliob
Page 19 and 20: -Rosenthal fibres and eosinophilic
Page 21 and 22: -no mitoses, endothelial proliferat
Page 23 and 24: Pineal region tumours:Pineocytoma:-
Page 25 and 26: -Dutcher (intranuclear) and Russell
Page 27 and 28: PRACTICAL TIPS:1. Know cellularity
Page 29 and 30: Fig 3. Normal neuron.Fig 4. Normal
Page 31 and 32: Fig 7. Reactive gliosis with increa
Page 33 and 34: Fig 11. Ischaemic (red) neuron with
Page 35 and 36: Fig 15. Sequestrated intervertebral
Page 37 and 38: Fig 19. Gemistocytic astrocytoma.Fi
Page 39 and 40: Fig 23. Pleomorphic xanthoastrocyto
Page 41 and 42: Fig 27. GBM: Necrosis.Fig 28. Glios
Page 43 and 44: Fig 31. Oligodendroglioma. Chicken-
Page 45 and 46: Fig 35. Myxopapillary ependymoma. M
Page 47 and 48: Fig 39. Choroid plexus papilloma wi
Page 49 and 50: Fig 43. Central neurocytoma with a
Page 51 and 52: Fig 47. Schwannoma. Twisted rope pa
Page 53 and 54: Fig 51. Neurofibroma.Fig 52. Mening
Page 55 and 56: Fig 55. Clear cell meningioma.Fig 5
Page 57 and 58:
Fig 59. Haemangioblastoma. The typi
Page 59 and 60:
Fig 63. ACTH secreting pituitary ad
Page 61 and 62:
Fig 67. Spindle cell oncocytoma of
Page 63 and 64:
Fig 71. Metastatic carcinoma. Tumou
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CSF/brain smear cytology - Rcpa.tv

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