Iowa and PINT trial - SIN :: Congresso 2011 - SocietÃ Italiana di ...

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Markers of transfusion needs in neonates• Anemia: haemoblobin (Hb)/haematocrit(Ht) values in relation to thereference ranges of Hb or Ht at different post natal ages.• Clinical status of the newborn, particularly in presence of severecardio-pulmonary diseases, or of symptoms of anemia suggestinginadequate tissue oxygenation, such as increase in oxygenrequirement, tachycardia, apnea, poor weight gain.• Reticulocyte counts < 100000/µL.• High blood lactate levels.• Hemodynamic changes detected by echocardiography.• Peripheral fractional oxygen extraction, or Splanchnic-cerebral cerebraloxygenation ratio measured by near infrared spectroscopy.• Spectroscopic Noninvasive Measurement of Hemoglobin.• Regional cerebral oximetry.• High concentrations of Vascular Endotelial Growth Factor as indicatorof insufficient oxygen delivery to tissues.
- Blood transfusions increase cerebral, splanchnic, and renaloxygenation in anemic preterm infants (Dani, 2010).- Splanchnic-cerebral cerebral oxygenation ratio as a marker ofpreterm infant blood transfusion needs (Bailey, 2011).SCOR = splanchnic-cerebralcerebral oxygenation ratio determined using near-infraredspectroscopy (NIRS).
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