Clinical Case Presentation #1 - Dorothy Dow, MD - Duke ...

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La Crosse Virus (LACV)•!•!•!•!Member of genusOrthobunyavirus, familyBunyaviridae.Vector is the Ochlerotatustriseriatus, formerly Aedestriseriatus, eastern treeholemosquitoUnlike West Nile virusinfections (more severe inadults) LACV more severe inchildren8-30% all encephalitis andMOST COMMON arboviralinfection in childrenHaddow, Andrew. PLoS One V 4(7); 2009
La Crosse County, Wisconsin1960: 1 st case 4 y/o girl died of “ruralencephalitis” (thought to havebeen infected in Minnesota).1964 Dr. Wayne Thompson andcolleagues isolate the virus(90-100 mm) from patients braintissueLarge, Medium, Small genomesegmentsL: viral polymeraseM: process into viralglycoproteins G1 (fusion) andG2! major determinant for viralneuroinvasivenessS: encodes N proteinViral envelope is host derivedPhoto courtesy of Dr Ray Baumann from the Dept. of Microbiology, University of Mississippi Medical Center
Page 1 and 2: Clinical Case PresentationDorothy D
Page 3 and 4: Further History•!•!•!•!•!
Page 5 and 6: LABS•! Initiallywbc 20.6 hg 13.6
Page 7: CONSULTBased on CSF, likely viral p
Page 11 and 12: LACE: La Crosse Encephalitis•! Pr
Page 13 and 14: Confirmed Case definitionLaboratory
Page 15 and 16: Incidence MapHaddow, Andrew. PLoS O
Page 17 and 18: Other Arbovirus•! West Nile:1 st
Page 19 and 20: In Summary•!•!•!•!La Crosse
Page 21: QUESTIONS

Clinical Case Presentation #1 - Dorothy Dow, MD - Duke ...

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