Vaccines: focus on adults - Summa Health System
Vaccines: focus on adults - Summa Health System
Vaccines: focus on adults - Summa Health System
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PNEUMOCOCCAL VACCINE13 valent c<strong>on</strong>jugated vaccine study for <strong>adults</strong>CAPITA Study (Community Acquired Pneum<strong>on</strong>iaImmunizati<strong>on</strong> Trial in Adults)• RCT trial in Netherlands• Design• 13 valent c<strong>on</strong>jugate vaccine (same as pediatricvaccine)• Placebo c<strong>on</strong>trolled (1:1); approx 85,000 subjects,> 65 years of age, community dwelling• Endpoints:• Primary-preventi<strong>on</strong> of CAP (serotype specific)• Sec<strong>on</strong>dary-all cause CAP, col<strong>on</strong>izati<strong>on</strong> (2000subjects), mortality, bacteremiaHak et al. Netherlands J Med. 2008; 66: 378-381
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