Health Hazards of Obesity Part 1(Dr Ciara O'Sullivan)

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Abdominal adipocytes & insulinresistance insulin insulinresistance sensitivityFFA’s leptin++TNF– +- adiponectinresistincomplement+++ + +++prostaglandins IL – 6 PAI – 1 steroids TGF–
Mechanisms of insulin resistance• Role of metabolically activeabdominal adipocytes–excessive lipolysis causes flux of freefatty acids which impair function of keyinsulin sensitive tissues–release of inflammatory substances(also accelerates cardiovasculardisease)
Page 1 and 2: Health hazards of obesityDr Ciara O
Page 3 and 4: Key points• Definition• Prevale
Page 5 and 6: Introduction• Excess bodyweight i
Page 7 and 8: Definition of obesity• BMI - weig
Page 9 and 10: Flight to Haasts Bluff
Page 16 and 17: Incidence of obesity according toba
Page 18 and 19: Metabolic associationsof obesity•
Page 20 and 21: Metabolic syndrome is stronglylinke
Page 22 and 23: Flight to Kings Canyon
Page 24 and 25: Usual role of insulin as ametabolic
Page 28 and 29: Free fatty acids impair functionof
Page 30 and 31: Inflammation acceleratescardiovascu
Page 32 and 33: Mortality• Obesity decreases life
Page 34 and 35: Obesity &mortalityProspective study
Page 36 and 37: Effect offitness onmortality21,925
Page 38 and 39: Economic costs of obesity• Swedis

Health Hazards of Obesity Part 1(Dr Ciara O'Sullivan)

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