pharmaceutical impurity analysis solutions - Lcms-connect.com

Gas Chromatography (GC)7890A/5975C GC/MS systemwith 7697A Headspace samplerIn combination with fl ame ionization detection (FID), GC is the standard choicefor the analysis of volatile organic impurities, such as residual solvents. The gaschromatography headspace method is used worldwide for residual solvent analysisin quality control laboratories because it closely follows ICH Q3C guidelines. Samplepreparation and introduction is via a static headspace which facilitates the selectiveintroduction of volatile solvents without contamination by mostly non-volatile drugsubstance or drug products. Therefore, the use of an FID detector helps preferentiallyidentify and quantify residual solvents. More recently, the combination of gaschromatography and mass spectroscopy (GC/MS) has been successfully used forconfi rmation and identifi cation purposes, highlighting the fl exibility of this technology.GC columns14