MAC 2009 – programme book (English - pdf - 3082 Kb) - MEMS

AbstractHsCRP, BNP,PAI, etc; What To Make Of AllThese Emerging Inflammatory Markers?Dr. Hamat HamdiInflammation is the process whereby the body system react to the stimuli such as trauma, geneticdefects, physical and chemical agents, tissue necrosis, foreign bodies, immune reactions and infections.It is a protective mechanism for us to survive. This process involved the production of theseveral markers. This inflammatory markers can be detected in the peripheral blood samples.Atherosclerosis which is a very significant process in the development of Ischemic Heart Disease.It also involved an inflammatory process but in the subclinical manner. However some of the inflammatorymarkers can be used to detect this process and can be used to predict the risk of developingIHD. These include Hs-CRP, fibrinogen, PAI-1, IL-6, adhesion molecules and etc. These markers hasbeen shown before to carry the risk of developing of IHD especially with Hs-CRP.In case of the myocardium has been injured either from ischemia, strain or stress, Brain NatriureticPeptide (BNP) will be released to protect the further injury. This BNP is very important marker to beused in conjunction with the clinical conditions to manage Congestive Heart Failure (CHF). It can beused to rule in or rule out of CHF as been recommended by the European Society (ESC) GuidelinesFor Heart Failure 2008.People with diastolic heart failure (DHF) with high BNP also has been shown to have high level ofCollagen Markers in the peripheral blood. This reflect that diastolic dysfunction may involved earlyfibrosis process that can be used to guide an aggressive treatment in this DHF group.As a conclusion, inflammatory markers and cardiac biomarker is important to be used with clinicalscenario to guide us to give a better care to the patients.17