Candida albicans.pdf - Academic lab pages - School of Biosciences

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C. albicans: Pathogenesis• Diphorphism - unicellular yeast (blastospores & chlamydospores)or different filamentous forms (hypha, pseudo-hyphae)• Phenotypic switching (white Vs opaque colonies) - expression ofadherence proteins• Sexual mating – alpha forms more virulent• Chromatin modification – Histone acetylation (Rtt109)…. Survivalof RO killing by phagocytes• Immune evasion :- C. albican Pra1 binds Factor H (FH) and and FHL-1 to controland inactivate complement- Secreted aspartic proteases (Saps) also inactivate compliment- Pra1 binds & activates plasminogen to plasmin involved inextracellular matrix degradationJong et al 2001, Infect. & Immunity; Gropp et al 2009, Mol. Immuno.; Luo et al 2009,Mol. Immuno.; Lopes da Rosa et al 2009, Microbiol.
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