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Roaccutane<br />

Declining within expectations<br />

400<br />

300<br />

200<br />

100<br />

0<br />

CHF m<br />

sales<br />

Q1 '99 Q1 '00 Q1 '01 Q1 '02 Q1 '03<br />

global (<strong>Roche</strong> & Chugai)<br />

-34 % 1<br />

1 local growth<br />

• US<br />

r<br />

– now two generics approved, one on<br />

the market in Q1 '03<br />

– general decline of the respective<br />

market segment by approx. -25 % in<br />

scripts vs. Q1 '02; in line with<br />

previous years<br />

• Pregnancy Prevention Program<br />

– in the EU recognized as a valuable<br />

safety initiative<br />

– CPMP harmonization requested and<br />

ongoing<br />

48

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