Limitations of Experimental Human Abuse Liability ... - immpact

3. When doing IN and IV ALA, should theextract from the ADF formulation be used?• Example of a potential IV ALA study: – tampering produces a less-than-pure substance (e.g., solutionis slightly viscous or contains particulates but can still loadinto a syringe)– it would be important to know if iv prescription opioidabusers would still like the product– questionable as to whether this could be ethically tested• “Evaluating these issues…is subject to practical andethical constraints that are always difficult, and oftenpresent insurmountable barriers toaccomplishment.” (Wright et al., 2006)