DNA microarray in DLBCL

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The New England Journal of Medicinesignatures were found to predict survival in the preliminarygroup, in the validation group, and in thegroup of all patients (Table 2).Individual genes that were not in these four signaturesbut that predicted the likelihood of survival in aunivariate analysis of the preliminary group (P
MOLECULAR PROFILING OF SURVIVAL IN DIFFUSE LARGE-B-CELL LYMPHOMAARelative Level ofExpression (log 2 )2¡2Germinal-center B-cell–likeGerminal-CenterB-Cell Signature0Type 3Activated B-cell–like20¡2Germinal-center B-cell–likeMHC Class IISignatureType 3Activated B-cell–like20¡2Germinal-center B-cell–likeLymph-NodeSignatureType 3Activated B-cell–like20¡2Germinal-center B-cell–likeProliferationSignatureType 3Activated B-cell–like20¡2Germinal-center B-cell–likeBMP6Type 3Activated B-cell–like20¡2Germinal-center B-cell–likeOutcome-PredictorScoreType 3Activated B-cell–likeBSubgroup of Diffuse Large-B-Cell LymphomaGerminal-center B-cell–like Type 3 Activated B-cell–likeGerminal-center B-cellsignatureMHC class II signatureLymph-node signatureProliferation signatureBMP6Outcome-predictorscore0.25 0.50 1.00 2.00 4.00Relative Level of Expression (¬ median value)CProbabilityof SurvivalNO. AT RISKQuartiles 1 and 2Quartiles 3 and 4Germinal-Center B-Cell–like1.00.8Quartiles 1 and 20.60.4Quartiles 3 and 40.2P
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DNA microarray in DLBCL

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