Pharmacokinetic Analysis of BE Data - BEBAC ⢠Consultancy ...
Pharmacokinetic Analysis of BE Data - BEBAC ⢠Consultancy ...
Pharmacokinetic Analysis of BE Data - BEBAC ⢠Consultancy ...
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<strong>Pharmacokinetic</strong> <strong>Analysis</strong> <strong>of</strong> <strong>BE</strong> <strong>Data</strong>NCA: AUC•Log-linear trapezoidal rule•Assumes exponential elimination•Log-linear interpolation between data points•Only valid for iv administration; sections inabsorption phase underestimated if applied to ev•If C = 0 or subsequent concentrations are equal,section calculated by linear trapezoidal•Totali= n−1Ci+1− CiAUC0− t≈ ∑ ( t1 )ni+− tiCi=1 i+1lnCiBioequivalence Assessment <strong>of</strong> Oral Dosage Forms: Basic Concepts and Practical ApplicationsLeuven, 5–6 June, 201310 • 68
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