Prevention of Post-Partum Haemorrhage with Misoprostol

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P r e v e n t i o n o f P o s t - P a r t u m H a e m o r r h a g e w i t h M i s o p r o s t o l Regimen A single dose of misoprostol 600 µg orally is indicated for prevention of PPH in settings where oxytocin is not available. The recommended dose does not change according to the woman’s weight. Course of Treatment Misoprostol should be administered immediately after delivery of the newborn. It is good practice to first do an abdominal palpation to confirm that there are no additional babies in utero. Contraindications History of allergy to misoprostol or other prostaglandin. Side Effects Temperature changes: Shivering, chills and/or fever are all commonly associated with misoprostol. Shivering is the most common side effect and is occasionally accompanied by fever. In the large WHO multicentre study using 600 µg oral misoprostol, shivering was experienced by 18% of women, but temperatures of over 38°C or 40°C were found in only 6 and 0.1%, respectively [Gülmezoglu 2001]. Similarly, when Derman et al. used 600 µg in rural India, shivering occurred in 52.2% of women, but fever in only 4.2% [Derman 2006]. The shivering is self-regulating and even if high temperatures occur, they are transient and settle with reassurance and symptomatic treatment. Gastro-intestinal effects: Transient diarrhoea, nausea and vomiting may occur following misoprostol, but are rare, occurring in less than 1% women [Gülmezoglu 2001]. An anti-emetic can be used if needed, but in general no action is required except to reassure the woman and her family. Breast feeding: Small amounts of misoprostol or its active metabolite may appear in breast milk. No adverse effects on nursing infants have been reported. Self-Administration In community settings where oxytocin is not available, there are ongoing programmes in which women are given misoprostol tablets for self-administration after delivery. Reports from these programmes suggest that this can be done safely and effectively, but further research is in progress that will clarify the matter. Those providing misoprostol in this way are advised to monitor its use, effectiveness and side-effects; and to make an effort to ensure that, in cases of multiple pregnancies, misoprostol is not administered until after all babies have been delivered.
P r e v e n t i o n o f P o s t - P a r t u m H a e m o r r h a g e w i t h M i s o p r o s t o l References Begley CM. A comparison of ‘active’ and ‘physiological’ management of the third stage of labour. Midwifery 1990;6:3-17. Derman RJ, Kodkany BS, Goudar SS et al. Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomized controlled trial. Lancet 2006;368:1248-53. Durocher J, Bynum J, León W, Barrera G, Winikoff B. High fever following postpartum administration of sublingual misoprostol. BJOG. 2010 Jun;117(7):845-52. Elati A, Elmahaishi MS, Elmahaishi MO, Elsraiti OA, Weeks AD. The effect of misoprostol on postpartum contractions: a randomised comparison of three sublingual doses. BJOG. 2011 Mar;118(4):466-73. Gülmezoglu AM, Villar J, Ngoc NT, Piaggio G, Carroli G, Adetoro L, et al. WHO multicentre randomised trial of misoprostol in the management of the third stage of labour. Lancet 2001 Sep 1;358(9283):689- 95. Gülmezoglu AM, Forna F, Villar J, Hofmeyr GJ. Prostaglandins for preventing postpartum haemorrhage. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD000494. DOI: 10.1002/14651858.CD000494.pub3. Hofmeyr GJ, Gülmezoglu AM, Novikova N, Linder V, Ferreira S, Piaggio G. Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and metaanalysis of maternal deaths and dose-related effects. Bull World Health Organ. 2009 Sep;87(9):666-77. Høj L, Cardosa P, Nielsen BB, Hvidman L, Nielsen J, Aaby P. Effect of sublingual misoprostol on severe postpartum haemorrhage in a primary health centre in Guinea-Bissau: randomised double blind clinical trial. BMJ 2005;331:723. McDonald SJ, Abbott JM, Higgins SP. Prophylactic ergometrine-oxytocin versus oxytocin for the third stage of labour. Cochrane Database of Systematic Reviews 2004, Issue 1. Art. No.: CD000201. DOI: 10.1002/14651858.CD000201.pub2. Mobeen N, Durocher J, Zuberi N, Jahan N, Blum J, Wasim S, Walraven G, Hatcher J. Administration of misoprostol by trained traditional birth attendants to prevent postpartum haemorrhage in homebirths in Pakistan: a randomised placebo-controlled trial. BJOG. 2011;118(3):353-61. Walraven G, Blum J, Dampha Y, Sowe M, Morison L, Winikoff B, Sloan N. Misoprostol in the management of the third stage of labour in the home delivery setting in rural Gambia: a randomised controlled trial. BJOG 2005;112(9):1277-83. World Health Organization. Guidelines for the prevention of postpartum haemorrhage. World Health Organization, Geneva, 2007. World Health Organization. Model List of
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