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i o d y n a m i c t i s s u eGuided tissue regenerationThe structural integrityof the extracellular matrix:A key factor in its clinical successThese characteristics of the Tecnoss manufacturing process morethan adhere to the safety requirements; a substantial cellular andvascular colonization of Protexa, for close contactand a gradual remodeling of the endogenous neo-tissue. In fact, it isthe collagen preserved in the integrated extracellular matrix whichhas a fundamental role in the tissue regeneration, as:a) It acts as a sound substrate for platelet activation and aggregation;b) It is able to attract and stimulate the differentiation of mesenchymalstem cells in the bone marrow;c) It increases the levels of proliferation of fibreblasts by 2/3 times ;d) Contact with it promotes the aggregation and subsequent plateletlysis, which is the very first stage of tissue healing.1) Salasznyk RM, et al. Journal of Biomedicine and Biotechnology (2004),1:24-342) Hsu FY, et al. Biomaterials (1999), 20: 1931-1936– The platelets are the key players duringthe first phase of the healing process,when, following a lesion, initially a fibrindeposit and the formation of blood clotstake place; This stage is characterized bysignificant activation of the chemical signsmediated by cytokines and growth factors.In fact, the primary post haemorrhagic clotformation process through platelet aggregationand lysis, determines the release ofboth the coagulation cascade factors andof the growth factors including PDGF,I’IGF1, I’IGF2, AND VEGF, which are knownfor their activating effects on fibroblasts.The identification of thesequence of events whichbring about guided tissueregeneration has allowed usto indentify the key factorsin the process of guiding; thesimultaneous presence of threefundamental components is theprerequisite for the ‘de novo’formation of tissue.– The fibroblastic precursors are derivedfrom mesenchymal bone marrow stemcells, once they are differentiated fibroblaststhrough collagen synthesis and othercomponents of the extracellular matrix,they become responsible for the secondphase of the guidance process.– An insoluble substrate, which acts as asuitable foundation to the process of tissueregeneration, and carries out the supportfunctions and guidance of the formationof new tissue. For example an integratedextracellular matrix.The continued progress in the comprehensionof biological mechanisms whichregulate morphogenesis of the tissue canalso be capitalized on. They can aid thedevelopment and expansion of both naturaland artificial products able to restore ormaintain the function of damaged tissues1, 2, 3and organs (tissue engineering)1) Griffith LG, Naughton G. Science (2002); 295:1009-142) Reddi AH. Tissue Eng (2000); 6: 351-593) Nakashima N, Reddi AH. Nature Biotechnology(2003); 9: 1025-32