346 <strong>Adverse</strong> <strong>Drug</strong> <strong>Effects</strong>: a nursing concernhalofantrine 129haloperidol 53, 63, 143, 207, 209halothane 63, 103, 106, 193headache 150–151heartfailure 128, 130–131valve lesions 128, 135Helicobacter pylori 318–319heparin 14, 21, 136, 140, 167, 197, 199hepaticfibrosis 103tumours 103, 107–108hepatitis 103, 106–107hepatocellular necrosis 103, 105–106hepatotoxicity 103–104, 270–271herbal medicine 269–271hirsutism 187, 193–194histamine 39–40, 42antagonists 87, 143, 147, 187homeopathy 270–274hormone replacement therapy 211–212,324–327hydralazine 53, 65, 116, 118, 122,150–151, 199–200, 206hydrochlorothiazide 146hydroxychloroquine 161hyperprolactinaemia 164–165hypersensitivity reactions 52–58type l 53–54type ll 54type lll 54–55type lV 55hypertension 128, 131–132, 150–151, 271hyperthyroidism 164, 166hypertrichosis 187, 193–194hypnotics 87, 153, 173, 187, 300hypoglycaemia 314hypoglycaemic agents 203hypotension 128, 132–133, 289–290hypothyroidism 164, 166–167ibuprofen 151, 158, 162idarubicin 97idiosyncratic effects 61–65illicit drugs 183–184imipramine 27, 35, 64, 103, 141, 193immunoglobulins 150–151immunosuppressants 14impotence 203–207indometacin (indomethacin) 14, 33, 79,82, 150–151, 158–159, 174inhibitor 46, 50insomnia 153insulin 150, 155interactionsdrug-drug 5, 15drug-nutrient 14interferon 187alpha 164, 167interleukin-2 114international normalized ratio (INR) 303interstitial nephritis 120–121interstitial pneumonitis 143intracranial hypertension 150–151iodine 59, 69–70, 187, 189contrast media 55, 143–144ion channels 44–45blockers 45modulators 45ipratropium 145iron salts 13–15, 82, 100ischaemic colitis 98isocarboxazid 14, 64isoniazid 28, 53, 56, 59, 62, 65, 103,105–107, 116, 150–151, 158, 162,169, 174, 199isoprenaline 35, 90isotretinoin 69, 134, 174kernicterus 77ketamine 44ketoconazole 13, 128, 164, 168–169, 203kidney function 111–112Korsakoff psychosis 179L-tryptophan 196labetalol 203lanolin 191lansoprazole 28large intestine 98–102Lariam 177laxatives 38, 101, 187, 199lemon oil 294leuprorelin 204levodopa 14–15, 19, 27, 95, 143, 150,153, 173–174, 177–178
Index 347libido 203–204licensing 246lichen planus 90, 92, 187–188lidocaine (lignocaine) 15, 44, 154lipid solubility 10–11liquid paraffin 97lisinopril 193lithium 64, 70, 92, 114, 118, 120, 150,153, 156, 158, 164, 166–167, 173,187, 204liver 102–107disease 108fibrosis 103, 107local anaesthetics 44, 54, 187creams 55loperamide 98lorazepam 31lupus nephritis 116Lyell syndrome 61lysergic acid (LSD) 59, 180, 184malabsorption 97malignant hyperthermia 63mania 174, 177–178margosa oil 271marijuana 164marjoram 153medication errors 227–232mefloquine 35, 53, 174, 177megaloblastic anaemia 136melissa 153melphalan 97, 210meningitis 150–151mepacrine 190mercaptopurine 103, 119mescaline 180metabolism 24–31, 74, 77–78, 84fast and slow acetylators 65genetics 30glucose-6-phosphate dehydrogenasedeficiency 61–63P450 isoenzymes 25, 84phase l reactions 24–25phase ll reactions 25metformin 97–98, 136–137methadone 31, 169methaemoglobinaemia 69, 136, 139–140methicillin 59, 121methotrexate 33, 97, 103, 107, 114, 119,136–137, 143, 155, 197methyldopa 47–48, 53–54, 59, 103, 122,136, 138, 164–165, 193, 199,203–206, 208–209methysergide 122, 128, 135metoclopramide 15, 64, 150, 156,164–165, 193, 204, 209metoprolol 28, 205metronidazole 54, 90, 136, 141, 291–292mexiletine 28mianserin 136miconazole gel 304minocycline 103, 163, 199mistletoe 271mitomycin 97, 143modulators 45molecule size 10–11monoamine-oxidase inhibitors (MAOI)14, 64, 100, 103, 128, 132, 153,158, 160, 174, 177, 179, 182, 184,206, 208morphine 27, 31, 33, 35, 39, 55, 79, 174,181, 187mouth 90–92ulcers 90, 92movement disorders 156–157multidrug resistance gene (MDR1) 222muscle relaxants 143myalgia 194–195myasthenic syndrome 156myocardial infarction 128, 133–135myoclonus 157myopia 158, 160myositis 194N-acetyltransferase 65nadolol 205naftidrofuryl 12, 82nalidixic acid 150, 187naloxone 35, 128narcotics 67, 87, 143nasal congestion 143nausea 95–97, 291–292negligence 233, 333neomycin 114, 158–159, 163, 191nephrogenic diabetes insipidus 120
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Adverse DrugEffectsA Nursing Concer
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ContentsPrefaceIntroductionixxiPART
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ContentsviiPART 3 THE PRACTICE —
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xAdverse Drug Effects: a nursing co
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Chapter 1Pharmacokineticeffects - a
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Pharmacokinetic effects - absorptio
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Chapter 2Pharmacokinetic effects -m
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Chapter 10Neurological, sensoryand
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Chapter 11Psychological effectsIn 1
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Ethics of drug development and test
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Compliance, patient education and e
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Complementary therapy 269For exampl
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