Twenty-five years of Research on Cytochromes P450 2B: To ...
Twenty-five years of Research on Cytochromes P450 2B: To ...
Twenty-five years of Research on Cytochromes P450 2B: To ...
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Summary1. <strong>P450</strong> <strong>2B</strong>4 exhibits remarkablec<strong>on</strong>formati<strong>on</strong>al flexibility with imidazoles<str<strong>on</strong>g>of</str<strong>on</strong>g> different size and shape as evidencedby X-ray crystallography and soluti<strong>on</strong>methods.2. Despite ~100 amino acid differences, theX-ray crystal structures <str<strong>on</strong>g>of</str<strong>on</strong>g> the 4-CPIcomplexes <str<strong>on</strong>g>of</str<strong>on</strong>g> <strong>P450</strong> <strong>2B</strong>4 and <strong>2B</strong>6 arealmost identical.3. How do we rec<strong>on</strong>cile these twoseemingly c<strong>on</strong>tradictory findings?
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