12. Farooq A, Plotnikova O, Chaturvedi G, Yan S, Zeng L, Zhang Q & Zhou MM (2003). Solution Structure ofthe MAPK Phosphatase PAC1 Catalytic Domain: Insights into Substrate-Induced Enzymatic Activation ofMKP. STRUCTURE 11, 155-164.13. Manzur KL, Farooq A, Zeng L, Plotnikova O, Koch AW, Sachchidanand & Zhou MM (2003). A DimericViral SET Domain Methyltransferase Specific to Lys27 of Histone H3. NATURE STRUCTURAL andMOLECULAR BIOLOGY 10, 187-196.14. Farooq A, Zeng L & Zhou MM (2003). 1H, 13C and 15N Resonance Assignments of the PTB Domain ofthe Signaling Protein Shc. JOURNAL of BIOMOLECULAR NMR 25, 255-256.15. Manzur KL, Farooq A, Zeng L & Zhou MM (2003). 1H, 13C and 15N Resonance Assignments of a ViralSET Domain Histone Lysine Methyltransferase. JOURNAL of BIOMOLECULAR NMR 26, 279-80.16. Farooq A, Zeng L, Yan KS, Ravichandran KS & Zhou MM (2003). Coupling of Folding and Binding in thePTB Domain of the Signaling Protein Shc. STRUCTURE 11, 905-913.17. Yan KS, Yan S, Farooq A, Han A, Zeng L & Zhou MM (2003). Structure and Conserved RNA Binding ofthe PAZ Domain. NATURE 426, 468-474.18. Koch AW, Farooq A, Zeng L, Colman DR & Zhou MM (2004). 1H, 13C and 15N Resonance Assignmentsfor the N-Cadherin Prodomain. JOURNAL of BIOMOLECULAR NMR 28, 87-88.19. Koch AW, Farooq A, Gruzglin G, Shan W, Zeng L, Colman DR & Zhou MM (2004). Structure of the N-Cadherin Prodomain Reveals a Cadherin Extracellular-Like Domain Fold Without Adhesive Characteristics.STRUCTURE 12, 793-805.20. Farooq A & Zhou MM (2004). Structure and Regulation of MAPK Phosphatases. CELLULAR SIGNALING16, 769-779.21. Farooq A & Zhou MM (2004). PTB or Not to Be: Promiscuous, Tolerant and Bizarro Domains Come ofAge. IUBMB LIFE 56, 547-556.22. Zhang Y, Yan Z, Farooq A, Liu X, Lu C, Zhou MM & He C (2004). Molecular Basis of Distinct InteractionsBetween Dok1 PTB Domain and Tyrosine-Phosphorylated EGF Receptor. JOURNAL of MOLECULARBIOLOGY 343, 1147-1155.23. Qian C, Zeng L, Farooq A & Zhou MM (2004). Resonance Assignments for the Endosomal AdaptorProtein p14. JOURNAL of BIOMOLECULAR NMR 30, 367-368.24. Qian C, Zhang Q, Wang X, Zeng L, Farooq A & Zhou MM (2005). Structure of the Adaptor Protein p14Reveals a Profilin-Like Fold With Distinct Function. JOURNAL of MOLECULAR BIOLOGY 347, 309-321.25. Zhang Q, Muller M, Chen CH, Zeng L, Farooq A & Zhou MM (2005). New Insights into the CatalyticActivation of the MAPK Phosphatase PAC-1 Induced by its Substrate MAPK ERK2 Binding. JOURNAL ofMOLECULAR BIOLOGY 354, 777-788.26. Sudol M, Recinos CC, Abraczinkas J, Humbert J & Farooq A (2005). WW or WoW — The WW Domains ina Union of Bliss. IUBMB LIFE 57, 773-778.27. Qian C, Wang X, Manzur K, Sachchidanand, Farooq A, Zeng L, Wang R & Zhou MM (2006). StructuralInsights of the Specificity and Catalysis of a Viral Histone H3 Lysine 27 Methyltransferase. JOURNAL ofMOLECULAR BIOLOGY 359, 86-96.28. Farooq A, Sudol M & Zhou MM (2006). Two Is Better Than One — Structure, Function and Mechanism ofProtein Domains Acting in Tandem. In “FOCUS on CELLULAR SIGNALING RESEARCH”, Leeds DTeditor, Nova Publishers; Chapter 5, 117-136.29. Ramsauer VP, Pino V, Farooq A, Carraway CAC, Salas PJI & Carraway KL (2006). Muc4-ErbB2 Complex<strong>Format</strong>ion and Signaling in Polarized CACO-2 Epithelial Cells Indicate That Muc4 Acts as an UnorthodoxLigand for ErbB2. MOLECULAR BIOLOGY of the CELL 17, 2931-2941.30. Carraway KL, Farooq A & Carraway CAC (2007). The Membrane Mucin Muc4 as a Modulator for theReceptor Tyrosine Kinase ErbB2. In “RECENT PROGRESS in CANCER RESEARCH”, Tang CK ed;Transworld Research Network (Kerala, India), pages 59-75.31. Seldeen KL, McDonald CB, Deegan JB & Farooq A (2008). Coupling of Folding and DNA-Binding in thebZIP Domains of Jun-Fos Heterodimeric Transcription Factor. ARCHIVES of BIOCHEMISTRY andBIOPHYSICS 473, 48-60.32. McDonald CB, Seldeen KL, Deegan BJ, Lewis MS & Farooq A (2008). Grb2 Adaptor UndergoesConformational Change Upon Dimerization. ARCHIVES of BIOCHEMISTRY and BIOPHYSICS 475, 25-35.33. Seldeen KL, McDonald CB, Deegan JB & Farooq A (2008). Thermodynamic Analysis of theHeterodimerization of Leucine Zippers of Jun and Fos Transcription Factors. BIOCHEMICAL andBIOPHYSICAL RESEARCH COMMUNICATIONS 375, 534-538.
34. McDonald CB, Seldeen KL, Deegan BJ & Farooq A (2008). Structural Basis of the Differential Binding ofthe SH3 Domains of Grb2 Adaptor to the Guanine Nucleotide Exchange Factor Sos1. ARCHIVES ofBIOCHEMISTRY and BIOPHYSICS 479, 52-62.35. Seldeen KL, McDonald CB, Deegan JB & Farooq A (2008). Evidence that the bZIP Domains of theTranscription Factor Jun Bind to DNA as Monomers Prior to Folding and Homodimerization. ARCHIVES ofBIOCHEMISTRY and BIOPHYSICS 480, 75-84.36. Seldeen KL, McDonald CB, Deegan BJ & Farooq A (2009). Single Nucleotide Variants of the TGACTCAMotif Modulate Energetics and Orientation of Binding of the Jun-Fos Heterodimeric Transcription Factor.BIOCHEMISTRY 48, 1975-1983.37. McDonald CB, Seldeen KL, Deegan BJ & Farooq A (2009). SH3 Domains of Grb2 Adaptor Bind toPXΨPXR Motifs within the Sos1 Nucleotide Exchange Factor in a Discriminate Manner. BIOCHEMISTRY48, In Press.C. RESEARCH SUPPORT1. Active:R01-GM083897 (Farooq) 08/01/2008-05/31/2013 10.8 calendarNIH/NIGMS $200,000Structural and Functional Studies of the Novel DBD Domain of MKP5The major goals of this project are to further our understanding of the role of various adaptors, enzymes andtranscription factors, with particular emphasis on MKP5 phosphatase, involved in regulating the MAP kinasesignalling cascade pertinent to cell growth and proliferation, cell survival and cancer.2. Pending:None
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