Experimental Design - Math Site

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Plackett Burman Designs• In general terms, fractional 2 level factorialdesigns are used to screen a large number ofpossibly influential variables to see if theytruly influence the response. We usuallyassume that the effects of second order andhigher terms (interactions) are much lessthan those of the constant and linear terms.CEI Inc.
Plackett Burman Designs• The most efficient of these “screening”designs is due to Plackett and Burman*• 12 runs can test up to 11 independentvariables (other PB designs have 20, 24, 28,and so on for the number of runs)* R.L Plackett and J.P. Burman, “The Design of Optimal MultifactorialExperiments”, Biometrika, 33, 305-325, (1946)CEI Inc.
Page 2 and 3: Topics CoveredIntroductionFull 2 Le
Page 4 and 5: History• Agricultural field trial
Page 6 and 7: George E.P. BoxCEI Inc.
Page 8 and 9: N-space and Real Space• It is oft
Page 10 and 11: Two Level Factorial Designs• If w
Page 12 and 13: Specific Volume of Ammonia• Four
Page 14 and 15: xP+1x-1 +1Tx-1x xFull Two Level Fac
Page 16 and 17: Effect of Temperature?V0.2950.215-1
Page 18 and 19: Effect of T, P Interaction?0.270.24
Page 20 and 21: Empirical Models• It is often pre
Page 22 and 23: The solution is easier if we use ma
Page 24 and 25: X t X =1 1 1 1-1 -1 1 1-1 1 -1 11 -
Page 26 and 27: 0.255β = (X t X) -1 X t y =0.040-0
Page 28 and 29: What if we havethree factors?CEI In
Page 30 and 31: Three Independent Variables• Our
Page 32 and 33: Exercise (left to student)Show that
Page 34 and 35: x 1 x 2 x 3-1 -1 -1-1 -1 1-1 1 -1-1
Page 36 and 37: However, you can confirm thatx 1 =
Page 38 and 39: Generators• I used the relationsh
Page 40 and 41: Resolution• In our 4 run subset o
Page 44 and 45: Plackett Burman Designs• The Plac
Page 46 and 47: Significance, Variances and ErrorBo
Page 48 and 49: NoteAlthough the V( ) notation sugg
Page 50 and 51: Aside on NomenclatureIf the predict
Page 52 and 53: estimation design”. Briefly, test
Page 54 and 55: We cannot use 2 level factorial des
Page 56 and 57: Three Level Factorial Designs2 Inde
Page 58 and 59: Example: More on v for NH 3Estimate
Page 60 and 61: Other Response Surface Designs• A
Page 62 and 63: Box Behnken Designs• The most wid
Page 64 and 65: 3 Factor Box Behnken DesignThe actu
Page 66 and 67: Use a Box Behnken design to estimat
Page 68 and 69: Question for DiscussionWhy isn’t
Page 70 and 71: Construction of a CCD in two factor
Page 72 and 73: Henry SchefféCEI Inc.
Page 74 and 75: Scheffé also came up with simplex-
Page 76 and 77: Let’s look at an example that tak
Page 78 and 79: Evolutionary Operation (EVOP)The te
Page 80 and 81: Evolutionary Operation, cont’dThe
Page 82 and 83: Geometry of 2 - D Simplex Methodnbr
Page 84 and 85: x 2 3 2y 0 3 2Z 20 5.26 11.1Clearly
Page 86 and 87: Geometry of 2 - D Simplex Methodnbr
Page 88 and 89: For the next iteration, w = (2, 0),
Page 90 and 91: Another observation from the graph
Page 92 and 93:
Warning #1The experimental runs use
Page 94 and 95:
Warning #2, and Possible CureA poss
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