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Discussion:Treatment of NMS:Dantrolene– Skeletal muscle relaxant– Inhibit calcium release fromsarcoplasma reticulum– Secondary to muscle relaxation,may decrease oxygenconsumption, heart rate &respiratory rate– Oral: 50-200mg/d– Intravenous 2-3mg/kg/d up to10mg/kg/dPharmacotherapyDopamine Agonists(Bromocriptine)– Central dopamine agonist– Oral: 2.5-10mg/d four times a daywith increments of 2.5mg tdsevery 24 hours until a response isseen or up to 60mg/d– Heptotoxicity – Hypotension– Acute psychosisThe evaluation and management of patients with neuroleptic malignant syndrome.Neurol Clin N Am 22 (2004) 389–411