cocaine guidance - Royal College of General Practitioners

17Appendix 1Cardiovascular problems including heart,blood pressure and circulation problems■ Blood pressure can be increased and needs tobe checked regularly. This can result from a period ofsustained use, and tends to return to normal after aperiod of abstinence. High salt intake can alsocontribute, where salt has been used in crackpreparation.■ Cocaine use can lead to rhythm changes andarrhythmias, which if untreated can be fatal. The riskof arrythmias increases greatly during binges, butreduces again during periods of low use/abstinence.Cannabis and cigarette smoking can increase thesearrhythmias.■ Angina, myocardial infarction and congestive heartfailure can result from reduced heart muscle function,increased heart size and arteriosclerosis of thearteries. 24■ Cocaethylene, formed by combination of cocaine andalcohol increases the risk of heart problems.■ Bacterial or viral endocarditis can result from injecting.■ DVT, more common than in heroin injectors.Liver problems■ Cocaine can exert stress upon the liver and heavyuse may lead to increased liver damage, especially ifthe patient is hepatitis C positive or is a heavy drinker.■ Acetone is used to recycle the cocaine remaining inthe pipe after smoking. It is toxic and can causeliver damage.■ Some patients will consume large amounts of alcoholto cope with the feeling of ‘come-down.’ This maymean that a whole bottle of spirits is taken in a veryshort time period, increasing the risk of damage.■ When cocaine and alcohol are taken together theyproduce cocaethylene, which is more toxic to the liverthan either substance alone.Kidney problems■ Renal artery spasm, thrombosis or embolism canresult in renal colic and/or kidney infarction.Central Nervous System■ Convulsions/seizures can be caused by increasedbody temperature and constriction of the small bloodvessels in the head, but cocaine and its breakdownproducts also reduce the epileptic threshold.Cocaethylene is especially potent in this regard, andits effect may last for up to 24 hours after ingestion.■ Cerebral vascular accidents (CVA) (strokes) resultingin cerebral haemorrhages, which are caused by delicateblood vessels breaking■ Hallucinations, delusions, paranoia, depression, anxiety.Blood Borne Viruses■ HIV, hepatitis B and C can be transmitted by all themain methods of drug use, via sharing injectingequipment and unprotected sex.■ Hepatitis C can lead to a multitude of symptomsincluding lethargy and depression.■ If the patient is HIV positive, drug use can increasethe viral load and decrease the CD4 count. Patientswith a low CD4 count or who are immuno-suppressedare at increased risk of infection.Sexual health■ Increased risk of contracting STIs as a result of unsafeand unprotected sex, due to the disinhibiting effectof stimulants.■ Anaesthetic effect, reduction of vaginal secretions andprolongation of sexual activity leading to genital trauma.■ Combined sildenafil (Viagra) and crack use cancause problems.■ People who buy sexual services may start using crack.This is becoming a small but significant population.■ Risk-taking leading to violence (especially in thesex industry).Other problems■ Chronic use can result in abdominal cramps, gastritisand ulcers.■ Cocaine use can cause immuno-suppression leadingto increased risk of infections.■ Complications can occur with coexisting physicalproblems such as epilepsy and sickle cell disease.■ Blood vessel spasm leading to blindness, to ischaemiain limbs and to infarction in the intestines.■ Cocaine can raise the blood glucose, and coupledwith poor eating habits results in an increased riskof diabetes. Usual diabetic symptoms, such as thirst,hunger, polyuria and fatigue can be masked bycrack taking.■ Anaemia can result from poor injecting techniques(resulting in loss of blood) and poor diet.■ Herpes can be passed from sharing pipes and sex.