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Ganesh Kumar Gudas * et al. /International Journal Of Pharmacy&Technologygel barrier. Therefore, such an effect is expected to be prominent during the initial face of the dissolutioncurve. However the results reported until now by many researchers suggest that tablet hardness has no orlittle effect on the release profile.Floating lag time studies of the tablets with different hardness between 4-5 Kg/cm 2 . It was observed thatwith increase in the hardness of the tablet the floating lag time was increased. Results of floating propertiesstudy reveal that all tablets had good floating properties are shown in Table 3. The incorporation of sodiumbicarbonate helps to improve floating properties by reacting with gastric fluid when dosage form <strong>com</strong>es incontact and produce carbon dioxide gas which entrapped inside the hydrophilic matrixes leads to increase involume of dosage form resulting in lowering of density and dosage form stars to float. Formulation F7 andF8 showed a floating lag time 1.55 and 1.42 , total floating time of 22 and 23 hrs respectively (Fig. 1(a&b))Table 3: Floating property and Swelling of formulations F1-F8FormulationFloating Lag TimeTotal Floating timeSwelling Index (%)Code(Min)(Hrs)F1 2.56±0.4 14 178.42F2 3.31±0.2 16 169.92F3 2.57±0.6 13 182.95F4 2.32±0.6 19 185.48F5 2.62±0.8 17 186.09F6 4.50±0.4 15 183.37F7 1.55±0.6 22 188.26F8 1.42±0.4 23 188.62IJPT | Sep-2010 | Vol. 2 | Issue No.3 | 549-556Page 554
Ganesh Kumar Gudas * et al. /International Journal Of Pharmacy&TechnologyFig. 1Dissolution profile of Formulation F1, F2, F3 & F4Cumulative % drug release1008060402000 2 4 6 8 10 12 14 16 18 20 22 24Time (Hrs)F1F2F3F4Cumulative % drugreleaseDissolution Profile of Formulation F5, F6, F7& F81008060402000 2 4 6 8 1012141618202224Time (Hrs)F5F6F7F8(a)(b)References1. Shrivastav A K, Wadhwa S, Ridhhurkar D. Oral sustained delivery of Atenolol from floating matrixtablet: Formulation and in vitro evaluation. INIST 2005; PP 367.2. Baumgartner S, Kristl J.; Optimization of floating matrix tablets and evaluation of their gastricresidence time. Int J Pharma; 2000; 195: PP 125-135.3. Yeole P.G, Khan S and Patel V F. Floating drug delivery system: needs and developments. Ind JPharm Sci 2005; 67(3) : PP 265-272.4. Hwang S J, Park K. Gastric retentive drug delivery systems. Crit Rev Ther Drug Carrier Syst 1998;15: PP 243-48.5. Arora S, Ali J. Ahuha A. Floating drug delivery system: a review. AAPS Pharma Sci Tech 2005; 6(3) Article 47.6. Deshpande A, Shah N, Rhodes C. Development of a novel controlled release system for gastricretention. Pharma Research 1997; 14(6): PP 815-819.IJPT | Sep-2010 | Vol. 2 | Issue No.3 | 549-556Page 555
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