Model-Based Drug-Development (MBDD) - WorldPharma 2010

The Need for Systems ApproachClinical Pharmacology & Therapeutics 2010Inherent in the development of systems clinical pharmacology is a need for modelsthat are physiologically realistic enough to provide accurate systems information yetretain sufficient simplicity to be computationally feasible - in other words, whatVicini [9] describes as “fit-for purpose” models. However, encouraging progresshas been made in predicting individual and even populationpharmacokinetics from models that combine biological systemsinformation with physicochemical drug characteristics [10].