CLRES 2300: Introduction to Systematic Reviews and Meta-Analysis ...

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Session 1Date9/29Background about systematic reviews/meta‐analysisFormulating a research question and study protocolInstructor:NayakTopics:1. Definitions of systematic review and meta‐analysis2. Why do we need systematic reviews and meta‐analyses?3. Difference between systematic reviews and narrative reviews4. Systematic reviews/meta‐analysis of RCTs versus other study designs5. Introduction to the Cochrane Collaboration6. Outline of steps in performing a systematic review, including:• Defining a research question• Defining inclusion/exclusion criteria• Developing a study protocolRequired Reading (prior to session):1. Egger Chapters 1, 2, 12, 252. Ross, et al. article (provided on CourseWeb)In‐class Exercise:Begin to draft a systematic review/meta‐analysis study protocol based on the Ross, et al. articleyou will be updating for the course final project. Specifically: 1) refine the research question, ifnecessary; 2) specify inclusion and exclusion criteria; and 3) create an inclusion/exclusioncriteria form.Homework Assignment 1:Using the Ross, et al. article that we have chosen for the course project, review the researchquestion, protocol, and inclusion/exclusion criteria listed in the article. Briefly answer thefollowing questions: Was the research question appropriately defined? Was it clear that aresearch protocol was developed prior to initiation of the study? Was this protocol explicitlystated? Were inclusion/exclusion criteria clearly stated? Is there anything that you might havedone differently regarding defining the research question, planning or presenting the studyprotocol, or choice of inclusion/exclusion criteria? Additionally, create and hand in aninclusion/exclusion criteria form created using the same criteria stated by the study authors(continuation of in‐class exercise).Homework Assignment 1 due Thursday October 1st
Session 2Date10/1Goals of literature searchHow to develop search strategies for online databasesInstructors:Nayak,HSL LibrariansTopics:1. Goals of literature search2. Databases (MEDLINE, EMBASE, etc.) & database‐specific search strategies3. Designing & implementing database search strategies (with demonstration ofMEDLINE search)4. Searching the grey literature, handsearching journals, contacting experts to findadditional literature5. Understanding the Cochrane Collaboration and navigation of the Cochrane websiteRequired Reading (prior to session):1. Egger Chapter 42. Cooper Chapter 4Suggested Reading :1. Petitti Chapter 4In‐class Exercise:Experiment with the different MEDLINE search features learned in class today (e.g., MESHterms, explode function) to identify search terms that can be used to find articles to update theRoss, et al. meta‐analysis. Begin to develop your own MEDLINE search strategy to update theRoss, et al. meta‐analysis.Homework Assignment 2:Review the search strategies indicated in the Ross, et al. meta‐analysis. Briefly answer thefollowing questions: Were the chosen databases appropriate to cover the relevant literature forthe research question? Would you have searched any additional databases? Were the searchstrategies for individual databases sufficiently broad to identify most of the literature on thetopic of interest within each of the databases? If there were limits placed on the search (e.g.language limits), were they appropriate? What steps (if any) were taken to find literaturebeyond the chosen databases? Additionally, design and hand in your own MEDLINE searchstrategy to identify articles to update this review (continuation of in‐class exercise).Homework Assignment 2 due Tuesday, October 6thSession 3 Date Managing references Instructors:
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CLRES 2300: Introduction to Systematic Reviews and Meta-Analysis ...

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