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J. Shobana * et al. /International Journal Of Pharmacy & TechnologyPregnancy and Birth DefectsPre-eclampsia and eclampsia are common obstetrical problem causing adverse effects on pregnancyoutcome. Elevated Homocysteine level is associated with pre-eclampsia and Eclampsia and the higherHomocysteine concentration in eclampsia compared to preeclampsia indicates its subtle association with theseverity of disorder as well. So, maternal Hyperhomocysteinemia seems to have causal role in the etiopathogenesisof pre-eclampsia/eclampsia. Management of Hyperhomocysteinemia in antenatal period taking into account the B-vitamin supplementation might help substantially to reduce the adverse pregnancy outcome 19 .Folic acid intake in the weeks before and after conception has been shown to decrease the number of neuraltube defects (NTD), such as spina bifida. Molloy et al 20 . conducted three separate case-control studies and foundthat women with a serum B 12 level of less than 300pg/ml were significantly more likely to have a baby born withneural tube defects. In another trial, the researcher found out that the low levels of a particular measure of B 12activity increased the risk of having a baby with a NTD by 5 times.Alzheimer’s diseasesResearch has shown that an elevated blood level of the sulphydryl amino acid Homocysteine termedHyperhomocysteinemia is an independent risk factor for vascular disease. Accordingly, the hypothesis thatHyperhomocysteinemia may also play a role in the pathogenesis of AD has been proposed. Bell and teamexamined several elderly patients who were hospitalized for acute depression and found a statistically significantnegative correlation between tHcy levels and cognitive ability 21 .Postmenopausal WomenReiss et al., 1999 22 , found basal Homocysteinemia is significantly higher in men than women. After menopausebasal Homocysteinemia increases significantly in women, approaching those in men. Premenopausal women areprotected from CHD by having favorable lipid profile and plasma tHcy level. After menopause this protection islost most probably due to estrogen deficiency. In another trial, they have studied the effect of folic acidIJPT | Dec-2010 | Vol. 2 | Issue No.4 | 551- 564Page 558
J. Shobana * et al. /International Journal Of Pharmacy & Technologysupplements for six months, on Hcy level in postmenopausal women. The result has shown an Significant(p
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