Question 3: Candida guilliermondii is

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• AZOLES• C. guilliermondii: susceptibility to FLU (75.2%)compared to C. albicans (97.8%) 1• No widespread azole resistance, most strainsshow panazole susceptibility• Empirical treatment with FLU• VRCZ more active than FLU (91%)= similar to C. glabrata 1• Resistance > efflux pumps, alteration of the targetenzyme of azoles (14 α-demethylase) 21.Savini et al., Mycoses 2010; 434-4412.Arendrup MC, Curr Opin Crit Care 2010; 445-452
• ECHINOCANDINS• The least echinocandin-susceptible yeast 1• Inherent and acquired echinocandin resistance:sporadically observed• MICs for echinocandins 2- to 100-fold higher forC. guilliermondii• Imperfect correlation between MICs and clinicaloutcome 2• Treatment success rate with an echinocandin 89%with an overall mortality of 19%. 1, 31. Colombo et al., AAC 2010; 1864-18712. Savini et al., Mycoses 2010; 434-4413. Chen et al., CMI 2009; 662-669
Page 1: Candida guilliermondiiDr. Karolien
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Page 11 and 12: Question 2 The incidence of candide
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Question 3: Candida guilliermondii is

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