3 - History of Anaesthesia Society

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was visited by mny friends, colleagues and patients. Reautiful floral tributes were presented to him. Harever, the celebrations were postponed temporarily, according to the report, while Picnot, then 75 years old, first finishe4 his sur'lery. Iater life In l896 Picnot left the Hague and went to live at Rue Crespel 4, Bn~sels, with his wife. From letters which he wrote to Dr Pinkhof living in the Hague, he was in poor health in 1900, yet racovere4 sufficiently by 1903 to treat some ptients. In the l905 Eenti~ts' Rgister, at the British Dental Association's library, his add re.;^ changed to Rue de Joncker 54, Brussels. By 1909, his health did not allow him to treat ptients any mre. His children remined well, but his wife was tmubled with arthritis and had ear trouble, so that t'iey were confined to the house. He writes that he was still in possession of hi^ dental chair, other furniture appertaining to the prsctice and also his dental instruments. An appreciation of Theoclore Picnot, when he died in 1910, ms given by the chairman of L\e Tandheelkundiq Genootschap. He said: 'I have never heard patients spak with more respct and appreciation abut their dentists than those of Picnot. All t'le rnembcrs of the Gencntsch~p who knew our honorary member will remember him with great admiration, and those who did not bow him with rmlch appreciation. me secrst Lay in his character ard behaviour - he was always correct in his operating technique, in his association with mtients and colleagues, in his appearance and in. every other way. Although he was a moifest, unassuming man, never seeking the limlight in his lmblic Aental professional life he, through his character, personality and his work, has contributed qreatly to raising the status of dentists and dentistry in this country. He will always remain in our thankful rememhrances.' van Wigyen, W. In meer eerbare banen. Amsterdam Wopi 1986, Academic thesis. de mar, m. Theorlore Picnot en zijn kast. Tandheelkudiye Studenten A.nak 1976; 310-314. van Wiggen, GJ.. Net Nederlandisch Tandheelkmdiq r~nootschan. Ned.Tijdschr.Tankheelkd. 1991; 98: 287-293. Vemelen-Cranch, DME. De geschi~lenis van de pijn bestrijdinq in de Tandheelkunde in Nederland. Ned.Tijdschr.Tandhee1kd. 1991; 99: 778-292.
Drs C.J.Niemegeers & F Awouters (~eerse, ~elgium) Janss~~n Reaea~xh has contri'xltsd t.r, anaesthesia mainly by introdllcing ptent and safe analqesics and neuroleptics. T'le developnent of tllesa corrrpou~ds started 37 years ago, when Paul Janssen evaluated the ph3m~coloqical activity of new mlscules chemically related to pethidine. It w.3~ t+ Stdrt of extensive studies on structure-activity relationship which led to very rptent and selective camp3unds providhq gieater clinical efficacy and safety (Figure 1). Figure 1. Pethidine-related ilevelopnent of potent ,Janssen narcotics and neuroleptics Early developtent of drugs Via the rmich base, th? propioah..nune R951 was synthesised and further elaborated to very ptent and specific narcotics and neuroleptics. When the 3-carbn bridge wss shortend to an ethyl group, narcotic activity increased; .3ul3?tituents on carbon 4 of the pipxidine ring were varied extensively to end up for optimal activity with the propioanilide group of fentanyl. Men tne 3-carbon bridge was length~n~rl by one methylene group as in the first butyrophznone, RllS7, neuroleptic activity
Page 3: Zhe History of Anaesthesia Society
Page 6 and 7: PARTICIPANTS AT TllE RO1TERDAM MEET
Page 8 and 9: haerrorrhage and the administration
Page 10 and 11: Pimot did not believe that dentists
Page 14 and 15: increased. In haloperidol the neuro
Page 16 and 17: 9000 times as potent as pethidine a
Page 18 and 19: Flacke JW et al. Comparison of morp
Page 20 and 21: he seems as dead'. It is clear from
Page 22 and 23: 1 Landon, H.C.Robbins Ed. The Colle
Page 24 and 25: dogs with a cl system. His reprt of
Page 26 and 27: the times when carbon dioxid is mst
Page 28 and 29: 'The salient characteristic of the
Page 30 and 31: Griffith, well imderstood the imprt
Page 32 and 33: Professor J J de 'Lange, Drs M A Cu
Page 34 and 35: Mter twenty mnuted he carried out a
Page 36 and 37: Dr J M Hot-ton (Cambridge) Denis Br
Page 38 and 39: -mtient, by mans of a cylinder fitt
Page 40 and 41: Professor H Reinhold (73nlssels) Hi
Page 42 and 43: In the early pst-mr perid the neces
Page 44 and 45: Most anaesthetics were still given
Page 46 and 47: Drs M Goerig, W Pothmann, H Polcar
Page 48 and 49: Figure 2. E@rthegs Device (1925) me
Page 50 and 51: Cohen EN et al. Occupational diseas
Page 52 and 53: Drs J Samarutel, A Yivic, E Kross,
Page 54 and 55: than 170 in 1991. TCIe EARS holds r

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