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MATERIAL SAFETY DATA SHEET Rohm and Haas Company

MATERIAL SAFETY DATA SHEET Rohm and Haas Company

MATERIAL SAFETY DATA SHEET Rohm and Haas Company

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ROHM AND HAAS COMPANY100 INDEPENDENCE MALL WESTPHILADELPHIA, PA 19106-2399PRODUCT: GOAL ® 1.6E HerbicideKEY: 893541-4DATE: 10/21/9710. STABILITY AND REACTIVITYInstabilityThis material is considered stable. However, avoid contact with ignition sources (e.g. sparks, open flame,heated surfaces).Hazardous Decomposition ProductsThermal decomposition may yield the following:- hydrogen chloride - hydrogen fluorideHazardous PolymerizationIncompatibilityProduct will not undergo polymerization.Avoid contact with the following:- acids - bases - amines - oxidizing agents - halogens - molten sulfur11. TOXICOLOGICAL INFORMATIONAcute DataOral LD50 - rat: >500 mg/kgDermal LD50 - rabbit: >5000 mg/kgEye Irritation - rabbit: severe irritationSkin Irritation - rabbit: severe irritationToxicity data for a compositionally similar material are listed below.Inhalation LC50 - rat: >22.64 mg/L for 4 hrSubchronic/Chronic DataThe following data pertains to studies conducted with the technical material, 70-75% active ingredient:Liver necrosis was observed in mice at 20 ppm <strong>and</strong> above; the overall NOEL was 2 ppm (0.3 mg/kg) in mice.Carcinogenicity DataThe following data pertains to studies conducted with the technical material, 70-75% active ingredient:No evidence of carcinogenicity was observed in long-term studies with rats. A slightly higher incidence (notstatistically significant) of liver tumors was seen in male mice at 200 ppm but not at 20 or 2 ppm, <strong>and</strong> not infemale mice at any of these doses.Mutagenicity DataThe following data pertains to studies conducted with the technical material, 70-75% active ingredient:Ames mutagenicity: PositiveMouse Lymphoma Point Mutation: PositiveIn vitro rat hepatocyte Unscheduled DNA Synthesis: NegativeIn vivo cytogenetic assay (rat): NegativeIn vivo chromosome aberration assay (mouse bone marrow cells): NegativePAGE 6 OF 9

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