Selective Effects by Valinomycin on Cytotoxicity ... - Cancer Research

National Cancer Institute. In: S. K. Carter, Y. Sakurai, and H. Umezawa (eds.),
New Drugs in Cancer Chemotherapy, pp. 153-175. Berlin: Springer-Verlag,
1981.
20. Goldin, A., and Vendit«, J. M. A prospective screening program: current
screening and its status. In: S. K. Carter, V. Sakurai, and H. Umezawa (eds.),
New Drugs in Cancer Chemotherapy, pp. 176-191. Berlin: Springer-Verlag,
1981.
21. Adam, G., Kleuser, B., Seher, J.-P., and Ullrich, S. Relation between 1C, Na+,
Ca2+, and proliferation of normal and transformed 3T3 mouse cells. In: A. L.
Boynton, W. L. McKeehan, and J. F. WhitfiekJ (eds.), Ions, Cell Proliferation,
and Cancer, pp. 219-244. New York: Academic Press, Inc., 1982.
22. Rieter, H., Kleuser, B., Kesper, A., and Adam, G. Different effects 'of growth-
inhibition in 3T3, 3T6 and SV40-3T3 mouse cells <strong>by</strong> low concentrations of the
IC-ion carrier valinomycin. Eur. J. Cell Btol., 33 (Suppl. 5V 29, 1984.
23. Seuwen, K., Steiner, U., and Adam, G. Cellular content of ribosomal RNA in
relation to the progression and competence signals governing proliferation of
3T3 and SV40-3T3. Exp. Cell Res., 154: 10-24, 1984.
24. Baisch, H., Göhde,W., and Unden, W A. Analysis of PCP-data to determine
the fraction of cells in the various phases of cell cycle. Radiât. Environ.
Biophys., 12: 31-39, 1975.
25. Rabinovitch, P. S. Regulation of human fibroblast growth rate <strong>by</strong> both noncycling
cell fraction and transition probability is shown <strong>by</strong> growth in 5-bromodeoxyuridine
followed <strong>by</strong> Hoechst 33258 flow cytometry. Proc. Nati. Acad. Sci.
USA, 80: 2951-2955, 1983.
26. Stiles, C. D., Desmond, W., Chuñan, L. M., Sato, G., and Saier, M. H.
Relationship of cell growth behavior in vitro to tumorigenicity in athymic nude
mice. Cancer Res., 36; 3300-3305,1976.
27. Adam, G., Kleuser, B., Seuwen, K., and Steiner, U. Cellular synergetics: celldensity
dependent regulation of population dynamics of mammalian cells in
vitro. In: L. Rensing and N. I. Jaeger (eds.). Tempera! Order, pp. 296-301.
Springer Series in Synergetics, Berlin: Springer-Verlag, 1985.
28. Adam, G., Steiner, U., Maier, H., and Ullrich, S. Analysis of cellular interactions
in density-dependent inhibition of 3T3 cell proliferation. Biophys. Struct. Mech.,
9: 75-82, 1982.
29. Rueckert, R. R., and Mueller, G. C. Studies on unbalanced growth in tissue
culture. I. Induction and consequences of thymidine deficiency. Cancer Res.,
20: 1584-1591, 1960.
GROWTH INHIBITION AND CYTOTOXICITY BY VAL
30. Cohen, L. S., and Studzinski, G. P. Con-elation between cell enlargement and
nucleic acid and protein content of HeLa cells in unbalanced growth produced
<strong>by</strong> inhibitors of DNA synthesis. J. Cell. Physiol., 69. 331-340,1967.
31. Felber, S. M., and Brand, M. D. <strong>Valinomycin</strong> can depolarize mitochondria in
intact lymphocytes without increasing plasma membrane potassium fluxes.
FEBS Lett., 750: 122-124,1982.
32. Pietrzyk, C., Geek, P., and Heinz, E. Regulation of the electrogenic (Na* +
K*)-pump of Ehrlich cells <strong>by</strong> intracellular cation levels. Biochim. Biophys. Acta,
513: 89-98,1978.
33. Rottenberg, H. ATP synthesis and electrical membrane potential in mitochon
dria. Eur. J. Biochem., 75. 22-28, 1970.
34. Stark, G., Ketterer, B., Benz, R., and Läuger, P. The rate constants of
valinomycin-mediated ion transport through thin lipid membranes. Biophys. J.,
77:981-994,1971.
35. Altman, P. L., and Katz, D. D. Cell Biology, Biological Handbooks I, p. 153.
Bethesda, MD: Federation of American Societies for Experimental Biology,
1976.
36. Adam, G., Alpes, H., Blaser, K., and Neubert, B. Cholesterol and phospholipid
content of 3T3 cells and transformed derivatives. Z. Naturforsch., 30c: 638-
642,1975.
37. Freudenberg, H., and Mager, J. Studies on the mechanism of the inhibition of
protein synthesis induced <strong>by</strong> intracellular ATP depletion. Biochim. Biophys.
Acta, 232: 537-555,1971.
38. Gordon, E. E., and de Hartog. M. <strong>Valinomycin</strong>-stimulated glycolysis in Ehrlich
ascites tumor cells. Biochim. Biophys. Acta, 762: 220-229, 1968.
39. Yamanishi, K. <strong>Effects</strong> of valinomycin on hexose transport and cellular ATP
pools in mouse fibroblasts. J. Cell. Physiol., 729:163-171,1984.
40. Seuwen, K., and Adam, G. Calcium compartments and fluxes are affected <strong>by</strong>
the src gene product of Rat-1 cells transformed <strong>by</strong> temperature-sensitive Rous
sarcoma virus. Biochem. Biophys. Res. Commun., 725: 337-345,1984.
41. Tsien, R. Y., Pozzan, T., and Rink, T. J. Calcium homeostatis in intact
lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly
trapped fluorescent indicator. J. Cell Biol., 94: 325-334,1982.
42. Breitbart, H., and Herzberg, M. Membrane mediated inhibition of protein
synthesis <strong>by</strong> valinomycin in reticulocytes. FEBS Lett., 32:15-18,1973.
43. Chen, K. Y., Kyriakidis, D. A., and Canellakis, E. S. The inhibition of the serumstimulated
increase of omithine decarboxylase <strong>by</strong> ionophores and local anes
thetics. Biochim. Biophys. Acta, 776: 72-78,1982.
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