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Neurotransmission Fact Sheet

Neurotransmission Fact Sheet

Neurotransmission Fact Sheet

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Nicotine and the BrainNonsmoker: Normal acetylcholine and receptorsAcetylcholine receptors help with respiration,heart rate, memory, alertness, muscle movement,pleasure, and well-being. In a synapse ofa nonsmoker, there is a normal amount ofacetylcholine and receptors, so the neuron isworking just like it should.New Smoker: Too many chemicals in the synapseNicotine is a similar shape to acetylcholine, so itfits into the same receptors. This makes neuron 1send messages much more often than it should.Addicted Smoker: Less acetylcholine and fewerreceptorsAfter a person has been smoking for a while,the brain decreases the amount of acetylcholineand the number of receptors. The brain doesthis to stop the neuron from sending too manymessages.Quitting “cold turkey”: Not enough acetylcholineand receptorsWhen nicotine use stops, the neuron is unableto send many messages because there is nolonger enough acetylcholine. There are alsofewer acetylcholine receptors. The user feelsuncomfortable and has withdrawal symptoms.Teacher copy: Module 2

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