Antimicrobial Susceptibility Testing Update - SWACM

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At the conclusion of this talk,you will be able to…… List some of the new recommendations forantimicrobial susceptibility testing andreporting as published in CLSI M100-S20andCLSI M100-S20S20-U (June 2010 <strong>Update</strong>). Discuss reporting results from testingcephalosporins and carbapenems againstEnterobacteriaceae. Describe strategies for implementation ofrevised breakpoints into clinical laboratorytesting protocols.
CLSI AST StandardsAugust 2010M100-S20Tables (January 2010)*– Revised cephalosporin & aztreonam breakpoints(Enterobacteriaceae)M100-S20-U (June 2010)– Revised carbapenem breakpoints (Enterobacteriaceae)M02-A10M07-A8Disk Diffusion Method (2009)**MIC Method (2009)**
Page 1: Antimicrobial SusceptibilityTesting
Page 5: Ceftriaxone Prescribing Information
Page 8 and 9: Enterobacteriaceae - Cephalosporins
Page 10 and 11: Table 2A Enterobacteriaceae♦ Dosi
Page 12 and 13: Why did CLSI lower cephalosporin,az
Page 14 and 15: Old ParadigmEmergence of a new β-l
Page 16 and 17: www.eucast.org
Page 18 and 19: MEROPENEM MIC distribution exampleB
Page 20 and 21: PK-PD PD Goal (“Target(Target”)
Page 22 and 23: Factors that Affect PK-PDPDTarget A
Page 24 and 25: What PK-PD PD data were used torevi
Page 26 and 27: Probability of Target AttainmentImi
Page 28 and 29: ImipenemProbability ofTarget Attain
Page 30 and 31: Enterobacteriaceae% Capture of Carb
Page 32 and 33: Meropenem MIC DistributionsEnteroba
Page 34 and 35: Expected Results forCarbapenemase-P
Page 36 and 37: Cumulative Ceftriaxone MIC Distribu
Page 38 and 39: Ceftriaxone MIC DistributionC. freu
Page 40 and 41: E. coli, Klebsiella spp., Proteus m
Page 42 and 43: Expected Results forESBL-ProducersC
Page 44 and 45: Why was cefepime breakpoint notlowe
Page 46 and 47: Why did cephalothin get moved?As re
Page 48 and 49: What narrow-spectrum cephalosporin
Page 50 and 51: Brief CLSI and FDABreakpoint (BP) S
Page 52 and 53:
Steps to ImplementingNew CLSI Cepha
Page 54 and 55:
Status of New Breakpoint Concentrat
Page 56 and 57:
Some concerns about the newbreakpoi
Page 58 and 59:
http://www.clsi.org/Content/Navigat
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Antimicrobial Susceptibility Testing Update - SWACM

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