Hepatoprotective and antioxidant activity of Zingiber chrysanthum ...

Hepatoprotective and antioxidant activity of Zingiber chrysanthum Rosec. rhizomes / Asian Journalof Traditional Medicines, 2011, 6 (6)Table 1. Biochemical parameters recorded seven days post- administration of CCl 4 and Z chrysanthum rhizome extracts toevaluate the hepatoprotective efficacy of AEZC and MEZCGroupsTreatment(Dose)Cholesterol(mg/dl)(mean±SE)Total Protein(g/dl)(mean±SE)Bilirubin(mg/dl)(mean±SE)Albumin(mg/dl)(mean±SE)UREA(mg/dl)(mean±SE)I Control 99.06±1.63 07.15±0.08 0.55±0.02 2.62±0.12 18.81±0.26II CCl 4 (3ml/kg.b.wt) 146.48±2.34 a 12.21±0.20 a 0.86±0.01 a 4.18±0.18 a 117.05±5.12 aIIIIVVVIVIIVIIIIXGroupsCCl 4 (3ml/kg.b.wt) +silymarin (3mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +AEZC (250 mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +AEZC (500 mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +AEZC (750 mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +MEZC (250 mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +MEZC (500 mg/kg b.wt.)CCl 4 (3ml/kg.b.wt) +MEZC (750 mg/kg b.wt.)Treatment(Dose)114.07±3.17 b 8.78±0.09 b 0.84±0.04 b 2.89±0.04 31.50±0.33 b127.63±3.17 bc 10.46±0.15 bc 0.88±0.06 b 3.83±0.10 bc 96.15±4.96 bcd123.12±1.65 bc 10.81± 0.13 bcd 1.45±0.07 bcd 3.63±0.14 bc 90.40±1.25 bcd115.52±1.55 b 10.25±0.11 bcd 0.54±0.03 cd 3.03±0.06 bcd 76.87±0.80 bcd124.93±1.57 bc 10.22±0.18 bcd 0.73±0.04 b 3.44±0.11 bc 32.47±0.29 bd116.28±0.64 b 9.40±0.09 bcd 0.69±0.04 d 3.12± 0.10 b 34.88±0.39 bd111.45±0.90 b 9.40±0.094 bcd 0.53±0.027 cd 3.66± 0.070 bcd 38.09±0.47 bdGlucose(mg/dl)(mean±SE)Triglyceride(mg/dl)(mean±SE)ALT (U/l)(mean±SE)AST (U/l)(mean±SE)Alkalinephosphatase (U/l)(mean ± SE)I Control 47.56±1.63 94.30±3.56 13.26±0.26 52.95±0.26 384.18±10.12II CCl 4 (3ml/kg.b.wt) 110.26±2.67 a 149.22±8.05 a 17.55±0.26 a 57.66±0.37 a 418.60±0.71 aIIIIVVVIVIIVIIIIXCCl 4 (3ml/kg.b.wt) +silymarin (3mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +AEZC (250 mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +AEZC (500 mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +AEZC (750 mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +MEZC (250 mg/kg. b.wt.)CCl 4 (3ml/kg.b.wt) +MEZC (500 mg/kg b.wt.)CCl 4 (3ml/kg.b.wt) +MEZC (750 mg/kg b.wt.)54.02±2.95 101.03±4.00 14.35±0.10 b 54.72±0.16 b 378.83±18.07110.92±2.35 bcd 124.52±8.97 bc 14.15±0.57 56.41±0.31 bd 158.35±8.78 bcd119.49±1.32 bcd 190.67±7.92 bcd 14.23±0.59 54.97±0.20 b 177.17±9.47 b127.31±2.00 bcd 102.95±3.26 14.34±0.39 55.13±0.19 bc 167.07±9.42 bcd32.97±2.06 bcd 103.45±3.18 d 14.93±0.47 b 55.91±0.41 bd 319.00±8.57 bcd42.50±1.10 bcd 64.93±2.57 bcd 14.23±0.62 55.17±0.26 b 310.28±6.65 bc47.84±1.15 bd 107.08±2.8 15.39±0.32 b 55.03±0.16 b 326.80± 8.15 bcdaP