Slide presentation - Clydebank Asbestos Group
Slide presentation - Clydebank Asbestos Group
Slide presentation - Clydebank Asbestos Group
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Time Trend of <strong>Asbestos</strong> Concentration in the Lungof Lung Cancer Patients in the Japanese GeneralPopulation日 本 人 一 般 集 団 における 肺 癌 患 者 の 肺 内 アスベスト 濃 度 の年 代 による 変 化Yuichi Ishikawa 1 , Yukitoshi Satoh 1 , Ayako Takata 2 , NorihikoKohyama 3 .1Department of Pathology, Cancer Institute, JapaneseFoundation for Cancer Research, Tokyo2School of Medicine, St. Marianna University, Kawasaki3National Institute of Industrial Health, KawasakiQuickTimeý DzTIFFÅiàèkǻǵÅj êLí£ÉvÉçÉOÉâÉÄÇDZÇÃÉsÉNÉ`ÉÉǾå©ÇÈǞǽDžÇÕïKóvÇ-ÇÅB石 川 雄 一 1、 佐 藤 之 俊 1、 高 田 礼 子 2、 神 山 宣 彦31( 財 ) 癌 研 究 会 癌 研 究 所 病 理 部2聖 マリアンナ 医 科 大 学 医 学 部3産 業 医 学 総 合 研 究 所GANN-KENThe JFCR Cancer Institute
Increased lung cancer and asbestos imports inJapan and US<strong>Asbestos</strong> import(x 10 4 t)9080<strong>Asbestos</strong> import (US)Lung cancer mortality(/10 5 )90807070606050Lung ca (US male)504030Lung ca (Jpn male)40302020100<strong>Asbestos</strong> import (Jpn)1910 1920 1930 1940 1950 1960 1970 1980 1990 2000100QuickTimeý DzTIFFÅiàèkǻǵÅj êLí£ÉvÉçÉOÉâÉÄÇDZÇÃÉsÉNÉ`ÉÉǾå©ÇÈǞǽDžÇÕïKóvÇ-ÇÅBGANN-KENThe JFCR Cancer Institute
■ Aim To investigate the role of environmental asbestos exposure torapidly increased lung cancer between 1950s and 1990s.■ Subjects, materials and methodsSubjects:Lung cancer patients from the Jpn general population.1950s 1970s 1990sN 9 52 60Gender (f:m) 3:6 22:30 30:30Metastatic cancers from colorectum: 1970s: 18 (f:m =9:9)Materials: Paraffin blocks from non-tumorous lung.<strong>Asbestos</strong> quantification: Chemical digestion by laboratory bleach.Ferruginous body counting: polarized light microscopy.QuickTimeý DzTIFFÅiàèkǻǵÅj êLí£ÉvÉçÉOÉâÉÄÇDZÇÃÉsÉNÉ`ÉÉǾå©ÇÈǞǽDžÇÕïKóvÇ-ÇÅBGANN-KENThe JFCR Cancer Institute
1600014000120001000080006000400020000QuickTimeý DzTIFFÅià èkǻǵÅj êLí£ÉvÉçÉOÉâÉÄÇDZÇÃÉsÉNÉ`ÉÉǾå©ÇÈǞǽDžÇÕïKóvÇ-Ç ÅBNumbers of asbestos bodies in the lung<strong>Asbestos</strong> bodies (/g dry)1970s1990sOccupational exposure,definiteOccupational exposure, susp.GANN-KENThe JFCR Cancer Institute2214-8N2684-9N28834175466510918-311053-111497-411777-413165-113761-113831-413868-1914138-1014624-414727-214766-114848-2014969-215269-415360-116324-816865-617217-217293-717348-417476-617554-917725-131429-131847-1133329-1134965-535005-135057-235085-235105-935144-1035197-1135272-635319-135342-135375-235408-1235416-1435471-1435513-135549-735689-1335725-235814-235852-1335915-135989-636515-1136652-136711-536867-337261-4Av(61-119)1950s
Comparisons of numbers of asbestos bodies:(1) Among 1950’s, 1970’s and 1990’s,(2) Between primary and metastatic lung cancers in 1970’s males.P
Conclusions• The concentration of 1970’s was significantly higherthan those of 1950’s and 90’s.• There were many lung cancer patients with so highlevels of asbestos deposition as seen in definite orsuspected occupational exposure.• <strong>Asbestos</strong> exposure is not deemed to be a main causeof the lung cancer increase from 1950s to 1990s.• But, in 1970s, primary lung cancer patients (male)had significantly higher asbestos deposition thanmetastatic patients.• Although the recent increase in lung cancer is notascribed to asbestos exposure, the results showedthat it played a certain role for development of malelung cancer in 1970s, which was the period both ofhigh growth of Japanese economy and of the highestconsumption of asbestos.QuickTimeý DzTIFFÅiàèkǻǵÅj êLí£ÉvÉçÉOÉâÉÄÇDZÇÃÉsÉNÉ`ÉÉǾå©ÇÈǞǽDžÇÕïKóvÇ-ÇÅBBack to AbstractGANN-KENNext ⇒The JFCR Cancer Institute
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