Pharmacophore of Morphine - CC

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Outline of Today’s Lecture1. Drug discovery without a leada. Penicillinb. Librium2. Lead discoverya. Random screeningb. Drug metabolism studiesc. Clinical observationsd. Rational approaches to lead discoverye. Drug discovery by computer-assisted drug design3. Lead modificationa. Pharmacophoreb. Structure modification (potency & therapeutic index & ADME)(1)Homologation; (2) Chain branching; (3) Ring-Chain transform; (4)Bioisosterism.4. Drug developmenta. General processb. Preclinical study and IND
PharmacophorePotencyThe relevant groups on a molecule thatinteract with a receptor and are responsiblefor the activity are collectively called thepharmacophore.The other atoms in the molecule arereferred to as the auxophore.ADME
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Pharmacophore of Morphine - CC

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