Feed Ingredient (Additive) - Federation of Animal Science Societies

Feed Additives andIngredientsAmey AdamsDivision of Animal FeedsCenter for Veterinary MedicinePresented at the April 28, 2008 FASS Meeting, Washington, DC

What’s new?• Food Additive Petitions– One complete– Three filed• Ingredient definitions– Four accepted– Three in process• Novel substances

Selenium Yeast Petition• Regulation published in FederalRegister– Allows selenium yeast in beef cattle limit-fed and free-choice mineral supplements• Use in horse supplements was throughthe AAFCO definition process

Other FAP Filings• Eubacterium– detoxification of trichothecene mycotoxins• Ammoniated Formic Acid– Amendment to use as a pH control agentin drinking water for swine• Conjugated linoleic acid (CLA)– Source of fatty acids for swine diets

Ingredient Definitions• Two animal products• One fermentation product• Two yeast products• One vitamin i definitioniti• One sequestrant product

Air Dried Animal Blood Cells(Air Swept Tubular Drying):• Is the product obtained by drying red and whiteblood cells which have been separated from theplasma of clean, fresh, whole animal blood withonly such amounts of plasma as might occurunavoidably in good processing methods. The bloodcells are dried by exposing the cells to a heated airstream and retaining them in the dryer until theyhave reached the specified moisture content. Theguaranteed analysis is: maximum moisture of 11%;and a minimum protein of 90%. If the productbears a name descriptive of its kind, origin, orcomposition it must correspond thereto.

Imported jackrabbit bones• Use allowed if meets current AAFCOdefinitions

Dried FermentationBiomass:• is a nonviable biomass product resultingfrom the production of the amino acids bythe fermentation of nonpathogenic,nontoxigenic, risk group 1 Escherichia coli.The product must contain a minimum of75% crude protein on a dry matter basis.The product is intended as a source ofprotein. Non-protein nitrogen content (whenpresent) must be guaranteed.

SodiumHexametaphosphate• GRAS as a sequestrant subject to GMFP’s• Table 87.5 in Section 87, Special PurposeProducts– Sodium Hexametaphosphate– 21 CFR 582.6760– Sequestrant– In accordance with good manufacturing orfeeding practice as a tartar control agent coatedon dry food products for reducing theaccumulation of dental tartar in dogs or cats.

Ingredient Definitions inprocess:• Two yeast products– Proposed 2 definitions• _______ yeast culture and• _______ yeast– Industry concern regarding changes– Investigator attempting to address• One vitamin definition– Vitamin i E with silicon dioxide id as a carrier– Proposed definition was rejected by IDC– CVM and AAFCO working on potential solution

Novel Substances• Contract with National Academy ofSciences– Evaluation of 3 novel substances• Evening primrose oil• Lutein• Garlic– Develop framework to assess safety of novelsubstances– Completion date – this fall

Humate/ humic shalesubstances• Are safety concerns– Need approval of Food Additive Petitionfor use in feed–Many ypproducts on the market• CVM evaluating its options• One issue - lack of analytical method

Camelina meal• Byproduct from biodiesel production– Safety concerns• Novel class of glucosinolates• Other potentially toxic substances• Presents animal and human food concerns– Firm working to address issues

Chromium Substances• Safety Concern Raised– Published scientific literature• Cellular damage, genotoxicity– Firms addressed issue• Chromium methionine complex– CVM withdrew use of regulatory discretion– AAFCO definition moved to Withdrawn section ofOP

Chromium Substances (cont)• Acceptable sources of chromium– Chromium propionate (def. 57.160)– Chromium tripicolinate (def. 57.155)• Use in swine diets only• Limited to 200 ppb• Chromium yeast is not acceptable– Same safety concerns as for otherorganic sources

Questions?