PROGRAM notesCONTINUED FROM PAGE 7Newest Class for 2006-07The <strong>MD</strong>-PhD Program received 477 applications (63% men;37% women) from undergraduates applying for admissionand funding from the MSTP grant. About 17% were invitedfor competitive interviews for MSTP funding offers. The newMSTP class includes: Mr. Jonathan Abraham (<strong>Harvard</strong>), Ms.Milena Andzelm (<strong>Harvard</strong>), Ms. Erin Chen (U-Chicago), Mr.Mark Lee (Yale), Ms. Devarati Mitra (Stanford), Mr. Yin Ren(MIT), Mr. Cameron Sadegh (MIT); and Ms. Yawei Yang(UCLA); and 2 deferrals from 2005 applicant pool: Ms. SarahHill (<strong>Harvard</strong>) and Ms. Karolina Maciag (<strong>Harvard</strong>); Mr.David Konieczkowski (Princeton) deferred until 2007.GalleryIn August, Ms. Amy Saltzman (Princeton), also a deferralfrom 2005, will join the program in the social sciences trackalong with Mr. Stephen Huffaker (U-Wisconsin), a recipientof the new NIH-Graduate Partners Program. The programalso welcomed Ms. Aurore Halkovich and Mr. Xavier Moisset,visiting French <strong>MD</strong>-PhD students sponsored by INSERM,who are participating in the summer course.Above: Students gatherat the annual summerbarbeque in 2005 onHMS Quad.Spring Dinner on June 6 honored the<strong>MD</strong>-PhD Class of 2006 and brought together,pictured from top:• Drs. Alan Michelson, Yonatan Grad, andMs. Linda Burnley• Dr. Vassilous Bezzerides, center, gave remarkson behalf of his graduating class. Shown withhim are his parents, Bandel and ElizabethBezzerides, and his wife, Ann Mitsakos.• Graduate Thomas Deuel shown here withhis mother Dr. Ruthmary K. Deuel.• Getting together at the Spring Dinner.Left: Jason Comanderat the Match Day onMarch 23, 2006.8HARVARD <strong>MD</strong>-PHD PROGRAM newsletter
For the RecordPhDs CompletedAndrew J. Aguirre, Health Sciences and Technology, BBS-Genetics (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Ronald A. Depinho,M.D.] Genetic Determinants of Pancreatic Ductal Adenocarcinoma (9/05).Siraj M. Ali, Health Sciences and Technology, Biophysics (GSAS) at <strong>Harvard</strong> <strong>University</strong>. [David Sabatini, M.D., Ph.D.] ATale of Two mTor Complexes (6/05).Zarine R. Balsara, Health Sciences and Technology, Immunology (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Michael N. Starnbach,Ph.D.] The interaction of Chlamydia trachomatis with mammalian host cells (5/06).Jakob Begun, Health Sciences and Technology, BBS Microbiology and Molecular Genetics (DMS) at <strong>Harvard</strong> <strong>University</strong>.[Frederick M. Ausubel, Ph.D.] Investigating the host-pathogen interaction using a Staphylococcus-Caenorhabditis elegansmodel system (5/05).Irene A. Chen, Health Sciences and Technology, Biophysics (GSAS) at <strong>Harvard</strong> <strong>University</strong>. [Jack W. Szostak, Ph.D.]Building a Protocell: Physical Aspects and Emergent Behaviors (9/05).Savita V. Dandapani, Castle, BBS-Cell and Developmental Biology (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Martin R. Pollak, M.D.]Role of alpha-actinin-4 in the kidney (7/06).John P. Dekker, Cannon, Neuroscience (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Gary I. Yellen, Ph.D.] Molecular Analysis of Gatingin Voltage - Dependent Ion Channels (5/06).Phillip A. Erwin, Cannon, BBS-Cell and Developmental Biology (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Thomas Michel, M.D.,Ph.D.] Dynamic S-Nitrosylation of Endothelial Nitric Oxide Synthase in Vascular Endothelial Cells (9/05).Anna F. Farago, Castle, BBS-Microbiology and Molecular Genetics (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Susan Dymecki, M.D.,Ph.D.] Uncovering Molecular and Spatial Predictors of Brainstem Identity (6/06).John R. Greenland, HST, Virology (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Norman Letvin, M.D.] Vaccine antigen expression andimmune responses (6/06).Robert S. Griffin, Health Sciences and Technology, Neuroscience (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Clifford Woolf, Ph.D.]Gene expression associated with neuropathic pain (9/05).Robert S. Hagan, Health Sciences and Technology, Biology at MIT. [Peter Sorger, Ph.D.] Regulation of the SpindleCheckpoint by Mad2 Binding Proteins (7/05).David H. Jung, Castle, BBS-Genetics (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Frederick W. Alt, Ph.D.] Cis-acting elements controllingantigen receptor gene assembly (6/05).Junne Kamihara, Health Sciences and Technology, Biology at MIT. [David E. Houseman, Ph.D.] Studies at theHemochromatosis (HFE) Locus: Gene conversions, Haplotypes, and an Association Analysis (12/05).Rita Khodosh, Health Sciences and Technology, Biology at MIT. [Paul A. Garrity, Ph.D.] Beach1 Functionally AntagonizesRab11 During Development and in Regulating Synaptic Morphology (7/05).Christina E. Mills, Health Sciences and Technology, Infectious Disease at <strong>Harvard</strong> <strong>School</strong> of Public Health. [MarcLipsitch, D.Phil] Transmission and Control of Pandemic Influenza (3/06).Bradley J. Molyneaux, Cannon, Neuroscience (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Jeffrey D. Macklis, M.D.] MolecularDevelopment of Corticospinal Motor Neurons (9/05).Carlos F. Paz, Cannon, BBS-Cell and Developmental Biology (DMS) at <strong>Harvard</strong> <strong>University</strong> [Charles J. Wietz, M.D.,Ph.D.] Circadian Clock Function in the Mammalian Retina (10/05).Robert S. Ohgami, Health Sciences and Technology, BBS- Cell and Developmental Biology (DMS) at <strong>Harvard</strong> <strong>University</strong>.[Mark D. Fleming, M.D., D. Phil] Identification and characterization of the Steap family of metalloreductases (5/06).James Rhee, Health Sciences and Technology, BBS-Genetics (DMS) at <strong>Harvard</strong> <strong>University</strong> [Bruce M. Spiegelman,Ph.D.] Partnership of HNF4a with the transcriptional coactivator PGC-1a in the regulation of hepatic glucose and lipidhomeostasis (9/05).Douglas Rubinson, Health Sciences and Technology, Biology at MIT. [Frank B. Gertler, Ph.D.] Knocked Down andKnocked Out: A lentiviral system for RNAi transgenesis and the Ena/VASP triple-knockout uncovers functions inmouse development (5/05).Safa A. Sadeghpour, Health Sciences and Technology, Brain & Cognitive Sciences at MIT. [Guosong Liu, M.D., Ph.D.]N<strong>MD</strong>A Normalization in Hippocampal Neurons: Activity-Dependent, Temporal, and Spatial Properties (8/05).Patrick Safo, Cannon, Neuroscience (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Wade G. Regehr, Ph.D.] The Role ofEndocannabinoids in Synaptic Plasticity as the Granule Cell to Purkinje Cell Synapse (6/06).Jay A. Shendure, Peabody, BBS-Genetics (DMS) at <strong>Harvard</strong> <strong>University</strong> [George M. Church, Ph.D.] Multiplex GenomeSequencing and Analysis (8/05).Bryan K-H. Sun, Holmes, BBS-Genetics (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Jeannie T. Lee, M.D., Ph.D.] Mechanisms of Tsixmediatedrepression of Xist (4/06).David Y. Takeda, Health Sciences and Technology, Pathology (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Anindya Dutta, Ph.D.]Regulation of Mammalian Replication Initiators During the Cell Cycle (6/05).Cullen M. Taniguchi, Castle, BBS-Cell and Developmental Biology (DMS) at <strong>Harvard</strong> <strong>University</strong> [C. Ronald Kahn, M.D.,D.Sc.] The Dissection of Insulin Signaling Isoforms In Vivo: Molecular Mechanisms of Hepatic Insulin Action (11/05).Vesselin T. Tomov, Health Sciences and Technology, BBS-Genetics (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Brian Seed, Ph.D.]Codon-Optimized and Reporter-Packaging Strains of HIV-1 (6/06).Griffin M. Weber, Health Sciences and Technology, Engineering & Applied Sciences (GSAS) at <strong>Harvard</strong> <strong>University</strong>. [LucilaOhno-Machado, M.D., Ph.D.] Data representation and algorithms for biomedical informatics applications (5/05).Ernest N. Yeh, Health Sciences and Technology, Electrical Engineering and Computer Science at MIT. [Daniel K.Sodickson, M.D., Ph.D.] Advanced Image Reconstruction in Parallel Magnetic Resonance Imaging: Constraints andSolutions (5/05).Glenn C-W. Yiu, Health Sciences and Technology, Neuroscience (DMS) at <strong>Harvard</strong> <strong>University</strong>. [Zhigang He, Ph.D.,B.M.] Signaling Mechanisms Limiting Axon Regeneration in the Adult Central Nervous System (5/06).GSAS = Graduate <strong>School</strong> of Arts and Sciences BBS = Biological and Biomedical Sciences DMS = Division of <strong>Medical</strong> SciencesNew PublicationsGrossman D, Ellertson C, Abuabara K, Blanchard K, Rivas FT. Do Product Labeling and PracticeGuidelines Deter Contraceptive Use? Am J Public Health. 2006 Jan 31Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ,Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA. High-resolution genomic profiles ofhuman lung cancer. Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9625-30.Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, JohnsonC, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and controlof CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15;202(4):529-39.Sarbassov dos D, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM. ProlongedRapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB. Mol Cell. 2006 Apr 21;22(2):159-68.Bailey SN, Ali SM, Carpenter AE, Higgins CO, Sabatini DM. Microarrays of lentiviruses for genefunction screens in immortalized and primary cells. Nat Methods. 2006 Feb;3(2):117-22.Sarbassov dos D, Ali SM, Sabatini DM. Growing roles for the mTOR pathway. Curr Opin Cell Biol.2005 Dec;17(6):596-603. Epub 2005 Oct 13. Review.Ali SM, Sabatini DM. Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylatesits hydrophobic motif site. J Biol Chem. 2005 Apr 4.Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW,Orr-Weaver TL. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bbas a cell cycle regulator. Dev Cell. 2005 Mar;8(3):435-42.Dulay MT, Baca QJ, Zare RN. Enhanced proteolytic activity of covalently bound enzymes in photopolymerizedsol gel. Anal Chem. 2005 Jul 15;77(14):4604-10.O'Hara FP, Beck E, Barr LK, Wong LL, Kessler DS, Riddle RD. Zebrafish Lmx1b.1 and Lmx1b.2 arerequired for maintenance of the isthmic organizer. Development. 2005 Jul;132(14):3163-73.Bernstein-Hanley I, Balsara ZR, Ulmer W, Coers J, Starnbach MN, Dietrich WF. Genetic analysis ofsusceptibility to Chlamydia trachomatis in mouse. Genes Immun. 2006 Jan 5.Sifri CD, Begun J, Ausubel FM. The worm has turned—microbial virulence modeled inCaenorhabditis elegans. Trends Microbiol. 2005 Mar;13(3):119-27. Review.Berry D, Ren J, Kwan CP, Sietsma DK, Sasisekharan R, Finklestein SP. Dimeric fibroblast growth factor-2enhances functional recovery after focal cerebral ischemia. Restor Neurol Neurosci. 2005;23(3-4):251-6.Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J,Chopra N, Russell RG, Sasisekharan R, Trock BJ, Lippman M, Calvert VS, Petricoin EF 3rd, Liotta L,Dadachova E, Pestell RG, Lisanti MP, Bonaldo P, Scherer PE.Adipocyte-derived collagen VI affectsearly mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stromamicroenvironment. J Clin Invest. 2005 May;115(5):1163-76.Carthon BC, Neumann CA, Das M, Pawlyk B, Li T, Geng Y, Sicinski P. Genetic replacement of cyclinD1 function in mouse development by cyclin D2. Mol Cell Biol. 2005 Feb;25(3):1081-8.Chang HH, Oh PY, Ingber DE, Huang S. Multistable and multistep dynamics in neutrophil differentiation.BMC Cell Biol. 2006 Feb 28;7(1):11Ohki K, Chung S, Ch'ng YH, Kara P, Reid RC. Functional imaging with cellular resolution revealsprecise micro-architecture in visual cortex. Nature. 2005 Feb 10;433(7026):597-603.Fujikawa SM, Chen IA, Szostak JW. Shrink-wrap vesicles. Langmuir. 2005 Dec 20;21(26):12124-9.Chen IA, Salehi-Ashtiani K, Szostak JW. RNA catalysis in model protocell vesicles. J Am Chem Soc.2005 Sep 28;127(38):13213-9.Vining MS, Bradley PL, Comeaux CA, Andrew DJ. Organ positioning in Drosophila requires complextissue-tissue interactions. Dev Biol. 2005 Nov 1;287(1):19-34. Epub 2005 Sep 19.Deuel TA, Liu JS, Corbo JC, Yoo SY, Rorke-Adams LB, Walsh CA. Genetic interactions between doublecortinand doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006 Jan5;49(1):41-53.Erwin PA, Mitchell DA, Sartoretto J, Marletta MA, Michel T. Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase. J Biol Chem. 2006 Jan 6;281(1):151-7.Erwin PA, Lin AJ, Golan DE, Michel T. Receptor-regulated dynamic S-nitrosylation of endothelialnitric-oxide synthase in vascular endothelial cells. J Biol Chem. 2005 May 20;280(20):19888-94.Mitchell DA, Erwin PA, Michel T, Marletta MA. S-Nitrosation and regulation of inducible nitricoxide synthase. Biochemistry. 2005 Mar 29;44(12):4636-47.HARVARD <strong>MD</strong>-PHD PROGRAM newsletter9
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