GENETICS OF STROKE IN 21 st CENTRY - SciReNe

Khalil Hamzi
the development of IS in Northern Han Chinese. Brain Research BulletinVolume 81, Issue 1,
15 January 2010, Pages 38-42 Nan Li 1, a, Zhiyi He, Jialiang Xu2, Fang Liu3, a, Shumin
Deng4, a, and Hui Zhang5. It remains difficult to conclude whether or not the association and
the role of the PDE4D gene in the pathogenesis of DALYs. In fact we have few studies, and
they are limited to a small number of patients. It would be interesting to study larger series of
different populations.Therefore, experimental studies on the function of PDE4D help to unveil
the mystery. PDE4D is a large family of PDE, which are the cAMP hydrolytic enzymes and
key molecules of signal transduction in several cell types, including smooth muscle cells of
blood vessels. These findings also apply to ALOX5AP (5 - lipoxygenaseactivatingprotein)
involved in the process of vascular inflammation which gives this gene of particular interest
mainly in its synergy with the processor of atherosclerosis (ElinLõhmussaar, and the Gene
ALOX5AP PDE4D Gene in a Central European Population of Stroke Patients, 2005).
i- "5-lipoxygenase-activating proteingene" gene (ALOX5AP) A second positive
relationship étudeIslandaise of stroke was introduced in 2004, it showed that the locus13q12
13est-linked gene with both myocardial infarction and cerebral infarction / TIA (Helgadottir
A, 2004). In this chromosomal region is the gene ALOX5AP involved in the metabolism of
leukotrienes, thus in atherosclerosis. The sequencing of the gene ALOX5AP revealed the
presence of SNP haplotype (HAPA), associated with a risk two times higher in ischemic
stroke and hemorrhagic. These results were répliquédans a Scottish study (Helgadottir A,
2005) and has not been found in a study of 640 American and 97% white (Meschia JF, 2005).
j-Other candidate genes and pathways other candidate genes have been studied for
possible association with ischemic stroke. They are listed in the webtable or discussed in
reviews. Among these genes, those involved in inflammation such as l'interleukine 1,
interleukin 6, TNF, Toll-likereceptor 4, P-selectin and E-selectin, C-reactive protein in lipid
metabolism such as apolipoprotein E, paraoxonase, epoxy), the release of nitric oxide. In most
cases, however, the results were negative or could not be replicated in future studies.
IDBM
11