The Toxicologist's Pocket Handbook

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Genetic Toxicology/Carcinogenesis 101Rao, G.N., Haseman, J.K., Grumbein, S., Crawford, D.D., and Eustis, S.L. (1990),Growth, body weight, survival and tumor trends in F344/N rats during aneleven-year period, Toxicol. Pathol. 18, 61.Tarone, R.E., Chu, K.C., and Ward, J.M. (1981), Variability in the rates of somecommon naturally occurring tumors in Fischer 344 rats and (C57BL/6NXC3H/HEN) F’ (B6C3F 1 ) mice, J. Natl. Cancer Inst., 66, 1175, cited inGad and Weil (1986).Walsh, K.M. and Poteracki, J. (1994), Spontaneous neoplasms in control Wistarrats, Fundam. Appl. Toxicol., 22, 65.Weisburger, J.H. and Williams, G.M. (1980). Chemical carcinogens, in Cassarett andDoull’s Toxicology: <strong>The</strong> Basic Science of Poisons, 2nd ed., Doull, J., Klaassen,C.D., and Amdur, M.O., Eds., Macmillan Publishing Co., New York, chap. 6.
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The Toxicologist’sPocket Handbook
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DedicationTo the Memory of My Fathe
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AcknowledgmentsThe author wishes to
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Table 19Table 20Acceptable and Cond
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Section 4Dermal ToxicologyTable 52
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Table 85 Reported Percentage Incide
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Table 113Table 114Table 115Table 11
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Table 141 Comparative Mammalian Org
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Table 168 Order for Reporting Toxic
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Table 208 Chemical Functional Group
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The Toxicologist’s Pocket Handboo
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10 The Toxicologist’s Pocket Hand
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Section 2General ToxicologyTable 21
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General Toxicology 25200PROBABILITY
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General Toxicology 27Table 24 Sugge
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General Toxicology 29Table 27 Compa
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General Toxicology 31Table 29 Clini
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General Toxicology 33Table 29 Clini
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General Toxicology 35Table 30 Auton
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General Toxicology 37Table 32 Hemat
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General Toxicology 39Table 34 Organ
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General Toxicology 41Table 36 Micro
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General Toxicology 43Table 38 Commo
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General Toxicology 45Freireich, E.J
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152 The Toxicologist’s Pocket Han
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Section 11Risk AssessmentFigure 8 T
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Risk Assessment 157Table 134 Major
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Risk Assessment 159Table 136 Epidem
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Risk Assessment 161CHEMICALRoute of
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Risk Assessment 163Figure 12 Relati
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Risk Assessment 165Figure 14 A dose
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Risk Assessment 167Table 139 Compar
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Risk Assessment 169Table 140 Typica
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Risk Assessment 171Table 143 Relati
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Risk Assessment 173Table 147 Summar
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Risk Assessment 175Table 149 Renal
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Risk Assessment 177Table 151 Develo
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Risk Assessment 179Table 154 Risk A
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Risk Assessment 185Assessment: Derm
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Section 12Human Clinical Toxicology
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Human Clinical Toxicology 189Table
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Human Clinical Toxicology 191Table
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Section 16Glossary—by SubjectCarc
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Glossary—by Subject 289Malignant:
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Glossary—by Subject 291Alanine am
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Glossary—by Subject 293Dermatitis
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Glossary—by Subject 295over a 5-d
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Glossary—by Subject 297Plasmid: A
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Glossary—by Subject 299Cytokines
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Glossary—by Subject 301T-cell/T-l
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Glossary—by Subject 303Medical de
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Glossary—by Subject 305epithelial
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Glossary—by Subject 307manufactur
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Glossary—by Subject 309Agenesis o
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Glossary—by Subject 311Estrus: Ph
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Glossary—by Subject 313Pseudopreg
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Glossary—by Subject 315Values are
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Glossary—by Subject 317Fence line
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Glossary—by Subject 319depends up
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Glossary—by Subject 321Slope fact
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Glossary—by Subject 323itself. hE
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