William Kaufman 1992-07-24 – PDF - Arthritis Trust of America

Medical data is for informational purposes only. You should always consult your family physician, or one of our referral physicians priorNow please read this patient’s entire history, physical examinationand her clinical course in response to 202 days of indi-K. You no doubt have a copy of Dr. Wright’s Preventionpatient will tolerate this lower daily dose without nausea.vidualized niacinamide therapy.Clinic: A CASE OF ARTHRITIS of March 1977 in which heThe clinical evidence is that this patient did have enough describes Mrs. Arthur’s excellent response to niacinamidehelp from 212 days of niacinamide therapy to improve her generalhealth, to make some of her seriously affected rheumatoid joints L. There is one more thing I wish to call to your atten-therapy.more mobile and pain free, provide her with more physical stamina tion:. Niacinamide tablets are an inexpensive medication forand muscle strength and also make her life pleasanter and more the treatment of joint dysfunction.comfortable than she had believed would ever be possible. Imerely cite this case to show the therapeutic power of niacinamideeven in as severe a case of rheumatoid arthritis as this. SincerelyWith kindest regards,F. Next I want to call your attention to the graph on page William Kaufman, Ph.D., M.D.153. The JRI’s of 455 persons in the untreated population werearranged in successive 5-year groups, thus making a linear graphwhich represented the central tendency of decline of thesucccessive Joint Range Indexes with age. The algebraic formulafor this line is not in this book. However, for this decliningline it is as follows: JRI = --0.42 x AGE +92.2.G. I am enclosing a larger version of “THE LINEARDECLINE IN THE JOINT RANGE INDEX WITH INCREAS-ING AGE” for you. In addition, I am enclosing another graphshowing how I used the above graph in patient care .The graph of Case # 330 Female Age 78 shows (A) herJRI before beginning niacinamide therapy and (B) her JRI after417 days of niacinamide therapy which has ascended thelinear graph from point A to point B. Her initial pretreatmentJRI was 70. thus slightly better than expected for her age. (Naturalvariation from the mean accounts for this difference.) HerJRl on her 417th day of treatment with niacinamide correspondedto what one would expect of a 28 year old woman.This large increase in her JRI indicated she had gained greatlyincreased joint flexibility with niacinamide therapy, a thing she alreadyknew from experience.. Showing a patient the progressthey have made with niacinamide therapy in this manner is veryencouraging to the patient. (Conversely if the patient reducesor stops niacinamide therapy, the loss of improvement is sostriking when plotted on this graph in terms of years of JRIflexibility lost that the patient usually becomes very faithful intaking the prescribed amounts of niacinamide.)U. I am also enclosing a reprint of my Tom Spies MemorialLecture, “Niacinamide: A most Neglected Vitamin,” whichwas published in the Journal of the International Academy ofPreventive Medicine in 1983. On pages 22 and 23 you can seewhat happened to the JRI ’ s of four patients having 12, 16, 17and 19 years of niacinamide therapy and how these rise to alevel much higher than the anticipated decline in the JRI with agein patients not treated with niacinamide.I .In addition, I am sending you a marked Xerox of A.Hoffer. Ph.D.. M.D. Treatment of Arthritis by Nicotinic Acidand Nicotinamide, Canadian Medical Association Journal 81,235-238. Aug. 15. 1959. This provides an accurate summaryof the history of my niacinamide work up to that date as well asDr. Hoffer’s six cases.J. In my series of patients, there have been no adverseside effects from the manner in which I prescribed niacinamidefor the treatment of joint dysfunction. I treated over 1500patients with niacinamide for joint dysfunction, and none of theseever experienced nausea. However, a doctor can prescribe dailydoses of niacinamide that are so large that this causes the patientto have nausea. When this occurs, it indicates that thedaily dose of niaicnamide prescribed was one gram a day higherthan the patient’s tolerance. If nausea occurs, the total daily intakeof niacinamide needs to be reduced by a gram a day; then the