I:\ltegeder\Testing Spg 05\MQ5 Spg 05.wpd - UNMC

Essay QuestionMini-Quiz #5Tuesday, April 26, 2005Prepare a list of the major physiologic effects, common drug forms, therapeutic uses and major side effects forestrogens and progestins. Be brief.Steroid hormone Estrogens Progestinsphysiologic effectscommon drug formstherapeutic uses1.Sexual maturation (andmaintenance): internal andexternal genitalia, breasts,female figure, skin texture,pigmentation, axillaries & pubichair pattern2. Long bone growth & closure ofepiphyses3. Increase thyroxin- and steroidbindingglobulins (SHBG), CBG,transcortin4. increase blood clotting factors5. Lipids: decrease total and LDLcholesterol & increase HDLcholesterol and triglycerides6. Normal endometrialdevelopment7. Regulate gonadotropinsecretion8. Decrease bone resorption1. Estradiol- (micronized oral;depot esters; topical: creams,patches, ring)2. Conjugated estrogens (oral,IM or IV, vaginal)3. Estrone, Estropipate,Esterified estrogens4. Ethinyl estradiol, Mestranol5. Diethylstilbestrol (notcommon)6. Dienestrol (cream)1. hypogonadism2. hypopituitarism3. replacement therapy4. postmenopausal hormonereplacement therapy5. oral contraceptives6. osteoporosis7. post-coital contraception8. dysmenorrhea1. Precursor for estrogens, androgensand adrenal steroids2. Inhibit endometrial growth3. Promote endometrial differentiation4. Maintenance of uterine functionduring pregnancy5. Normal menstruation, ovulation,fertility6. Increases basal body temperature7. Alveolar and secretorydevelopment in breast8. Depressant effects9. Promotes glycogen storage10. Stimulates lipoprotein lipase andfat deposition1. Progesterone (oral, IM, creams,suppositories, IUD2. Synthetic progestins such asmedroxyprogesterone acetate: (oral,IM), hydroxyprogesterone caproate3. Synthetic progestins related totestosterone: 19-nor derivatives suchas norethindrone, norgestrel(levonorgestrel), ethynodiol,norethynodrel, norgestimate,desogestrel, gestodene1. hormone replacement therapy2. postmenopausal hormonereplacement therapy3. contraceptives: oral, IM4. endometrial hyperplasia5. endometriosis6. metastatic endometrial or breastcancer7. post-coital contraception7