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6/21/2012PROOF?Compared to Conventional ventilation:• reduced lung expression of inflammatory cytokines –IL-1β, IL-6, IL-8, IL-10, TGF, adhesion molecules, mRNA• reduced pathological injury - less hyaline membrane formation, lessalveolar leukocyte infiltration and less airway epithelial damageImai Y, Kawano T Am J Respir Crit CareMed 1994, 150:1550-15547