Management of Constipation - Bowel Cancer UK
Management of Constipation - Bowel Cancer UK
Management of Constipation - Bowel Cancer UK
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% over 12 weeksEfficacy in chronic constipation:≥3 SCBM/week (primary endpoint)3530252023.6***24.7***19.5**23.6***23.9**23.5**30.9***28.4***151011.39.612.1 12.050Camilleri 11(n=1924)Tack 2(n=713) (91% F)Quigley 3(n=641) (87% F)Camilleri 4(n=620) (88% F)SCBM = spontaneous complete bowel movementsPlacebo Prucalopride 2 mg Prucalopride 4 mg**p≤0.01 vs. placebo***p≤0.001 vs. placebo1Camilleri et al. Gastroenterology 2008;134:A548. 2 Tack et al. Gut 2009;58:3573Quigley et al. Aliment Pharmacol Ther 2008;29:315. 4 Camilleri et al. N Engl J Med 2008;358:2344The 4 mg dose has not been licensed since no incremental benefit wasdemonstrated versus the 2 mg dose
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